血清S-100β、BUN联合APACHE Ⅱ评分评估老年脓毒症患者预后的价值  

Value of serum S-10oβ,BUN combined with APACHE Ⅱ score in evaluating the prognosis of elderly patients with sepsis

作　　者：胡海强 谢勇 江怡 Hu Haiqiang;Xie Yong;Jiang Yi(Xinyu Beihu Hospital,Xinyu,Jiangxi 338000,China;Xinyu Hospital of Traditional Chinese Medicine,Xinyu,Jiangxi 338000,China)

机构地区：[1]江西省新余北湖医院,江西新余338000 [2]江西省新余市中医院,江西新余338000

出　　处：《现代临床医学》2024年第4期284-286,290,共4页Journal of Modern Clinical Medicine

基　　金：新余市科技计划项目(20223091008)。

摘　　要：目的:探讨血清中枢神经特异性蛋白β(S-100β)、血尿素氮(BUN)联合急性生理学及慢性健康状况评分系统Ⅱ(APACHEⅡ)评分评估老年脓毒症患者预后的价值。方法:选取2022年4月至2023年6月新余北湖医院收治的102例老年脓毒症患者,根据APACHE Ⅱ评分将其分为轻、中、重3组,按改良Rankin量表将患者分为预后良好组与预后不良组,比较各组S-100β、BUN、APACHE Ⅱ评分的差异,并分析S-100β、BUN与APACHE Ⅱ评分的相关性,以及三者评估老年脓毒症患者预后的价值。结果:重度组的S-100β、BUN、APACHE Ⅱ评分高于中、轻度组,预后不良组的S-100β、BUN、APACHE Ⅱ评分高于预后良好组(P<0.05);S-100β、BUN与APACHE Ⅱ评分呈正相关(r=0.458、0.479,P<0.05);ROC曲线分析显示,S-100β、BUN联合APACHEⅡ评分评估老年脓毒症患者预后的曲线下面积为0.928,高于三者单独评估。结论:S-100β、BUN联合APACHEⅡ评分对老年脓毒症患者预后有较高的评估价值。Objective:To explore the value of serum S-10Oβ,BUN combined with APACHE Ⅱ score in evaluating the prognosis of elderly patients with sepsis.Methods:102 elderly patients with sepsis admited to Xinyu Beihu Hospital from April 2022 to June 2023 were selected.They were divided into mild,moderate,and severe groups based on the APACHE Ⅱ score.Meanwhile,they were divided into a good prognosis group and a poor prognosis group using the modified Rankin scale.The differences in S-100β,BUN,and APACHE Ⅱ score were compared among the groups.The correlations between S-100β,BUN,and APACHE Ⅱ score were analyzed as well as the value of the three in evaluating the prognosis of elderly sepsis patients.Results:The S-10Oβ,BUN,and APACHE Ⅱ score of the severe group were higher than those of the moderate and mild groups;the S-10oβ,BUN,and APACHE Ⅱ score of the poor prognosis group were higher than those of the good prognosis group(P<0.05);S-100β and BUN were positively correlated with APACHE Ⅱ score(r=0.458,0.479,P<0.05);ROC analysis showed that the area under the curve of S-10Oβ,BUN combined with APACHE Ⅱ score in evaluating the prognosis of elderly sepsis patients was 0.928,which was higher than that evaluated by the three alone.Conclusion:The combination of S-100β,BUN,and APACHE Ⅱ score has relatively high value in evaluating the prognosis of elderly patients with sepsis.

关 键 词：老年脓毒症 S-100Β BUN APACHEⅡ评分 预后 

分 类 号：R56[医药卫生—呼吸系统]