口服细菌疫苗研究进展  

Research Progress of Oral Bacterial Vaccine

作　　者：付来颖 王双 岳华[1] 魏炜[1,2] 郑迪威 FU Laiying;WANG Shuang;YUE Hua;WEI Wei;ZHENG Diwei(State Key Laboratory of Biochemical Engineering,Key Laboratory of Biopharmaceutical Preparation and Delivery,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;School of Chemical Engineering,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室生物药制备与递送重点实验室,北京100190 [2]中国科学院大学化学工程学院,北京100049

出　　处：《药学进展》2024年第6期412-420,共9页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金(No.52203185,No.22108284,No.U20A20361)。

摘　　要：口服细菌疫苗接种便捷,患者依从性高,可同时激活黏膜免疫、体液免疫和细胞免疫,是目前疫苗研究的前沿热点。然而,消化道环境的复杂性、递送载体的缺乏等因素极大地制约了口服细菌疫苗的稳定性和防治效果。近年来,合成生物学和材料学等技术的快速发展为应对上述挑战提供了全新的机遇。综述围绕口服细菌疫苗的作用机制,介绍了基于全细菌和细菌组分的口服疫苗的研究进展,总结了新型口服细菌疫苗的工程化策略及其在恶性肿瘤和病毒感染等适应证中的应用,进一步探讨了口服细菌疫苗递送系统的发展趋势,以期为未来口服细菌疫苗的研发提供参考。Oral bacterial vaccines are currently a hot topic in vaccine research,owing to such advantages as ease of administration,enhanced patient compliance,and their ability to induce mucosal immunity,humoral immunity,and cellular immunity simultaneously.Nonetheless,the stability and efficacy of these vaccines are hindered by the complexities of the gastrointestinal environment and the absence of efficient delivery systems.In recent years,the rapid development of synthetic biology and materials science technologies has provided opportunities for addressing the above challenges.This review offers a comprehensive overview of the immunological mechanisms underlying oral bacterial vaccines,recent research advancements concerning whole bacteria and bacterial components-based vaccines,innovative engineering strategies adopted in their development,and their applications in tumors and viral infection.In addition,several promising strategies for the delivery of oral bacterial vaccines have been thoroughly discussed,aiming to provide some valuable insights for future research in this importantfield.

关 键 词：口服疫苗 工程细菌 黏膜免疫 疫苗递送 

分 类 号：R392-33[医药卫生—免疫学] R945[医药卫生—基础医学]