外泌体糖组学在生物医药领域的应用研究进展  

Progress of Researchon theApplicationof Exosomal GlycomicsinBiomedicine

作　　者：王小蕾 郝嘉乐 傅庚辰 孙宏宇 于广利[1,2] 李国云 WANG Xiaolei;HAO Jiale;FU Gengchen;SUN Hongyu;YU Guangli;LI Guoyun(Ministry of Education Key Laboratory of Marine Drugs,Shandong Provincial Key Laboratory of Glycoscience and Glycotechnology,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China;Qingdao Marine Science and Technology center,Laboratory of Marine Drugs and Biological Products,Qingdao 266237,China)

机构地区：[1]海洋药物教育部重点实验室,山东省糖科学与糖工程重点实验室,中国海洋大学医药学院,山东青岛266003 [2]青岛海洋科技中心,海洋药物与生物制品功能实验室,山东青岛266237

出　　处：《药学进展》2024年第6期450-462,共13页Progress in Pharmaceutical Sciences

基　　金：国家自然科学基金青年项目(No.31600646);泰山学者攀登计划(No.TSPD20210304);国家级大学生创新创业训练计划(No.202120423066);山东省重大科技创新工程(No.2021ZDSYS22)。

摘　　要：外泌体上含有丰富的糖链,这些糖链携带大量生物信息,在外泌体介导的机体各个生物学过程中发挥重要作用。外泌体上异常变化的糖链可作为疾病的生物标志物和治疗靶标。此外,外泌体作为药物载体时,其靶向性的提高与表面糖复合物的修饰相关。综述系统介绍了外泌体中糖组、糖组学研究方法及其在生物医药领域的应用进展,为基于糖组学的外泌体在生物医药领域深入研究和应用提供参考。Exosomes are rich in glycoconjugates,which carry a lot of biological information and play an important role in various biological processes mediated by exosomes.Abnormally altered glycoconjugates in exosomes can be used as disease biomarkers and therapeutic targets.In addition,when exosomes are used as drug carriers,the improvement of their targeting is related to the modification of the surface glycoconjugates.This paper systematically reviews the glycomics in exosomes,the research methods of glycomics and their application in the field of biomedicine,aiming to provide some reference for the in-depth research and application of exosomes in the biomedicalfield based on the perspectiveofglycomics.

关 键 词：外泌体 糖组学 糖基化 癌症 生物标志物 药物靶点 药物递送载体 

分 类 号：Q819[生物学—生物工程]