支气管扩张合并感染患者血清PCT、CRP、iNOS、IL-33水平变化及其与预后的关系  

Changes of serum PCT,CRP,iNOS and IL-33 levels and prognosis in patients with bronchiectasis and infection

作　　者：陈晶晶 丁帆 杨萍 CHEN Jing-jing;DING Fan;YANG Ping(Department of Laboratory,Wuhan Sixth Hospital,Affiliated Hospital of Jianghan University,Wuhan 430014,Hubei,China;Department of Cardiovascular Medicine,Wuhan Sixth Hospital,Affiliated Hospital of Jianghan University,Wuhan 430014,Hubei,China)

机构地区：[1]江汉大学附属医院·武汉市第六医院检验科,湖北武汉430014 [2]江汉大学附属医院·武汉市第六医院心血管内科,湖北武汉430014

出　　处：《川北医学院学报》2024年第7期924-927,共4页Journal of North Sichuan Medical College

基　　金：湖北省卫生健康委员会联合基金项目(WJ2019H339)。

摘　　要：目的:探讨支气管扩张合并感染患者血清降钙素原(PCT)、C反应蛋白(CRP)、诱生型一氧化氮合酶(iNOS)、白细胞介素33(IL-33)水平的变化及其与预后的关系。方法:选取140例支气管扩张合并感染患者为观察组,根据感染程度分为轻度感染组(累及单个肺叶,n=48)、中度感染组(累及单侧肺叶,n=52)及重度感染组(累及双侧肺叶,n=40);根据预后分为存活组(n=95)和死亡组(n=45);另选80名体检健康者为对照组。比较各组对象血清PCT、CRP、iNOS、IL-33水平;多因素Logistic回归分析影响气管扩张合并感染预后的因素;ROC曲线分析血清各指标对患者预后的预测价值。结果:观察组患者血清PCT、CRP、iNOS、IL-33水平均高于对照组(P<0.05);各组感染血清PCT、CRP、iNOS、IL-33水平比较:重度感染组>中度感染组>轻度感染组(P<0.05);死亡组患者血清PCT、CRP、iNOS、IL-33水平高于生存组(P<0.05)。回归分析显示,PCT、CRP、iNOS、IL-33水平均是影响气管扩张合并感染预后的因素(P<0.05)。ROC分析显示,PCT、CRP、iNOS、IL-33水平联合预测支气管扩张合并感染预后的敏感度为91.12%,AUC为0.970。结论:支气管扩张合并感染患者血清PCT、CRP、iNOS、IL-33水平呈高表达,联合检测有利于评估患者病情和预后。Objective:To explore the changes of serum procalcitonin(PCT),C-reactive protein(CRP),inducible nitric oxide synthase(iNOS)and interleukin-33(IL-33)in patients with bronchiectasis and infection,and their relationship with the prognosis.Methods:A total of 140 patients with bronchiectasis and infection were prospectively selected as the observation group.They were divided into mild infection group(involving single lung lobe,n=48),moderate infection group(involving unilateral lung lobes,n=52)and severe infection group(involving bilateral lung lobes,n=40)according to the severity of infection.According to the prognosis,the patients were divided into survival group(n=95)and death group(n=45).Meanwhile,80 healthy individuals were selected as the control group.Serum PCT,CRP,iNOS and IL-33 levels were compared in groups,multivariate Logistic regression was used to analyze the factors affecting the prognosis of tracheal dilation combined with infection,and ROC curves were used to analyze prognostic value of the indexes.Results:Serum PCT,CRP,iNOS and IL-33 levels in observation group were higher than those in control group(P<0.05).Serum PCT,CRP,iNOS and IL-33 levels in severe infection group,moderate infection group,and mild infection group decreased in order(P<0.05).Serum PCT,CRP,iNOS and IL-33 levels in death group were higher than those in survival group(P<0.05).Logistic regression analysis showed that PCT,CRP,iNOS and IL-33 levels were prognostic factors in patients with bronchodilation and infection(P<0.05).ROC curve analysis showed that the sensitivity and AUC of the combination of PCT,CRP,iNOS and IL-33 for predicting the prognosis of bronchiectasis complicated with infection were 91.12%and 0.970.Conclusion:Serum PCT,CRP,iNOS and IL-33 levels in patients with bronchiectasis and infection are high.Joint detection is helpful for evaluating the condition and prognosis.

关 键 词：支气管扩张 感染 降钙素原 C反应蛋白 诱生型一氧化氮合酶 白细胞介素33 预后 

分 类 号：R562.2[医药卫生—呼吸系统]