Ligand Controlled Stereodivergent Construction of 1,3-Nonadjacent Stereocenters via Nickel-Catalyzed Reductive Cyclization/Cross-Couplings  

作　　者：PAN Qi KONG Wangqing 

机构地区：[1]The Institute for Advanced Studies,Wuhan University,Wuhan 430072,Hubei,China

出　　处：《Wuhan University Journal of Natural Sciences》2024年第3期195-197,共3页武汉大学学报（自然科学英文版）

基　　金：Supported by the National Natural Science Foundation of China (22171215 and 22301225);the Hubei Provincial Outstanding Youth Fund (2022CFA092);Hubei Provincial Natural Science Foundation (2023AFB034)。

摘　　要：Molecules with multiple stereocenters are widely present in biologically active natural products and pharmaceuticals. These molecules exhibit great three-dimensional structural diversity, which can affect the strength and selectivity of protein-ligand interactions^([1]). Therefore, the precise synthesis of each stereoisomer is very important in medicinal chemistry. In the past 40 years, asymmetric catalysis has developed rapidly, and a variety of methods has been developed to construct chiral compounds containing single or adjacent stereocenters^([2]).

关 键 词：CENTERS STEREO PRECISE 

分 类 号：O621.251[理学—有机化学]