S100A8/A9在高发肿瘤转移前微环境中的作用机制及研究现状  

Mechanism and research progress of S100A8/A9 in the microenvironment before high-risk tumor metastasis

作　　者：明海霞 刘兆华[1,2,3,4] 王彦君 申明 陈彦文 李杨 杨玲玲 梁乾坤[1] MING Hai-xia;LIU Zhao-hua;WANG Yan-jun;SHEN Ming;CHEN Yan-wen;LI Yang;YANG ling-ling;LIANG Qian-kun(School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Basic Discipline of Integrative Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Gansu University Key Laboratory for Molecular Medicine&Chinese Medicine Prevention and Treatment of Major Diseases,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Key Laboratory of Chronic Diseases for Prevention and Treatment of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China;Intensive Care Unit,The Affiliated Hospital of Gansu University Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学基础医学院,甘肃兰州730000 [2]甘肃中医药大学中西医结合基础学科,甘肃兰州730000 [3]甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州730000 [4]甘肃省中医药防治慢性疾病重点实验室,甘肃兰州730000 [5]甘肃中医药大学附属医院重症医学科,甘肃兰州730000

出　　处：《中国临床药理学杂志》2024年第13期1991-1995,共5页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省"双一流"科研重点基金资助项目(GSSYLXM-05);甘肃省科技厅自然科学基金资助项目(20JR5RA178,20JR10RA320);甘肃省中医药研究中心开放课题资助项目(zyzx-2020-zx2);甘肃省教育科技创新基金资助项目(2021CXZX-745);甘肃中医药大学科学研究与创新基金资助项目(2020KCZD-4,2021KCZD-1);甘肃中医药大学中西医结合基础学科科研培育基金资助项目(2023-2024-8)。

摘　　要：S100钙结合蛋白A8/A9(S100A8/A9)能通过结合多种通道蛋白诱导原发肿瘤细胞向远端靶器官迁移,促进肿瘤转移微环境的形成,在机体免疫和炎症反应中发挥重要作用。为防治肿瘤转移和侵袭提供了新的靶点和思路。本文主要综述了S100A8/A9在多种高发肿瘤中的作用机制和对相关通道蛋白的表达,以期能为肿瘤的预防及诊治提供新的策略。S100 calc-binding protein A8/A9(S100A8/A9)can induce the migration of primary tumor cells to distant target organs by binding multiple channel proteins,promote the formation of tumor metastasis microenvironment,and play an important role in the immune and inflammatory response of the body.It provides a new target and idea for the prevention and treatment of tumor metastasis and invasion.This paper mainly reviewed the expression and mechanism of S100A8/A9 on related channel proteins in a variety of high incidence tumors,in order to provide a new strategy for tumor prevention,diagnosis and treatment.

关 键 词：肿瘤 炎症 免疫 S100钙结合蛋白A8/A9 

分 类 号：R97[医药卫生—药品]