辐射对药代动力学的影响  

Effects of radiation on pharmacokinetics

作　　者：宗杰 张海晖 窦桂芳 孟志云 顾若兰 吴卓娜 朱晓霞 胡瑄 甘慧 ZONG Jie;ZHANG Hai-hui;DOU Gui-fang;MENG Zhi-yun;GU Ruo-lan;WU Zhuo-na;ZHU Xiao-xia;HU Xuan;GAN Hui(Beijing Institute of Radiation Medicine,Academic of Military Medical Science,Beijing 100850,China)

机构地区：[1]军事医学研究院辐射医学研究所,北京100850

出　　处：《中国临床药理学杂志》2024年第13期1996-2000,共5页The Chinese Journal of Clinical Pharmacology

基　　金：北京市自然科学基金资助项目(7202148)。

摘　　要：辐射主要来自医用射线、工业用射线、核废物和天然射线等,分为电离辐射和非电离辐射。研究电离和非电离辐射对药物代谢的影响,了解辐射后药物在机体内的吸收、分布以及辐射条件下消除快慢等情况,可对临床用药进行合理的指导。本文综述了辐射对不同药物的药代动力学的影响,阐述辐射状态下不同药代动力学参数的变化,并讨论变化产生的原因。Radiation mainly comes from medical radiation,industrial radiation,nuclear waste and atmospheric ultraviolet radiation,etc.,radiation is divided into ionizing radiation and non-ionizing radiation.Studying the effects of ionizing and non-ionizing radiation on drug metabolism,understanding the absorption and distribution of drugs in the body after radiation and the speed of elimination under radiation conditions can provide reasonable guidance for clinical medication.This article reviews the effects of radiation on the pharmacokinetics of different drugs,elaborates the changes of different pharmacokinetics under radiation state,and discusses the reasons for the changes.

关 键 词：药代动力学 辐射 动力学参数 药物代谢酶 

分 类 号：R97[医药卫生—药品]