血清CCL11、G-CSF水平评估慢性阻塞性肺疾病急性加重风险的价值  

Value of serum CCL11 combined with G-CSF in evaluating the risk of acute exacerbation of chronic obstructive pulmonary disease

作　　者：赵沙沙 王圆圆 张春丽 陈雪阳 冯宪军[1] Zhao Shasha;Wang Yuanyuan;Zhang Chunli;Chen Xueyang;Feng Xianjun(Respiratory Intensive Care Unit,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院呼吸重症监护室,新乡453100

出　　处：《中国实用医刊》2024年第10期16-19,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨血清CC趋化因子配体11(CCL11)、粒细胞集落刺激因子(G-CSF)水平评估慢性阻塞性肺疾病(COPD)急性加重风险的价值。方法回顾性抽取2020年9月至2023年9月新乡医学院第一附属医院收治的COPD患者89例,依据入院时病情分为急性加重组(36例)与非急性加重组(53例)。另抽取同期体检健康者60例作为健康对照组。采用酶联免疫吸附法检测血清CCL11、G-CSF水平,采用受试者工作特性曲线下面积(AUC)分析二者对COPD急性加重风险的评估价值。结果非急性加重组和急性加重组血清CCL11、G-CSF水平高于健康对照组,且急性加重组上述指标高于非急性加重组(P<0.05)。血清CCL11和G-CSF水平预测COPD急性加重风险的AUC分别为0.70(95%CI 0.659~0.753)、0.83(95%CI 0.779~0.874),两者联合预测的AUC为0.91(95%CI 0.867~0.961)。结论血清CCL11、G-CSF在COPD急性加重期呈高表达,其对评估COPD急性加重风险有一定临床价值,且二者联合检测的评估价值更高。Objective To investigate the value of serum CC chemokine ligand 11(CCL11)combined with serum granulocyte colony-stimulating factor(G-CSF)in evaluating the risk of acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 89 COPD patients admitted to the First Affiliated Hospital of Xinxiang Medical University from September 2020 to September 2023 were retrospectively selected,and they were divided into an exacerbation group(36 cases)and a non-exacerbation group(53 cases)according to disease condition at admission.In addition,60 healthy patients were selected as the healthy control group during the same period.The levels of serum CCL11 and G-CSF were detected by enzyme-linked immunosorbent assay,and the area under the curve(AUC)of receiver operating characteristic curve was used to analyze the value in assessing the risk of COPD exacerbation.Results The levels of serum CCL11 and G-CSF in the non-exacerbation grorp and exacerbation group were higher than those in the healthy control group,and levels of the above indicators in the exacerbation group were higher than those in the non-acute plus recombinant group(P<0.05).The AUC of levels of serum CCL11 and G-CSF in predicting the risk of COPD exacerbation were 0.70(95%CI:0.659-0.753)and 0.83(95%CI:0.779-0.874),respectively,and the AUC of the combination of the two indicators in prediction was 0.91(95%CI:0.867-0.961).Conclusions Serum CCL11 and G-CSF are highly expressed in the acute exacerbation of COPD,both of which have certain clinical value in assessing the risk of acute exacerbation of COPD,and the evaluation value of the combination of the two indicators is higher.

关 键 词：CC趋化因子配体11 粒细胞集落刺激因子 慢性阻塞性肺疾病 急性加重 

分 类 号：R563.9[医药卫生—呼吸系统]