银杏酮酯治疗血管相关性疾病的物质基础及作用机制研究进展  

Chemical Constitution and Pharmacological Mechanism of Ginkgo biloba Extract 50 in the Treatment of Vascular Related Diseases

作　　者：李星源 刘爱军 LI Xingyuan;LIU Aijun(School of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Department of Pharmacy Research,Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]山东中医药大学药学院,济南250355 [2]上海中医药大学附属岳阳中西医结合医院药学研究室,上海200437

出　　处：《中国药学杂志》2024年第12期1074-1081,共8页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82273984);国家重点研发计划项目资助(YS2019YFC170045);中医学-中成药临床评价平台项目资助(A1-U21-205-902);上海中医药大学附属岳阳中西医结合医院基金项目资助(2021yygm01)。

摘　　要：银杏用于治疗瘀血阻络、胸痹心痛、中风偏瘫等病症。银杏酮酯是我国使用“双重吸附、双重去除”等技术自主研发出的新型银杏叶提取物,其提高了有效成分银杏总黄酮和银杏内酯的稳定性,降低了毒性成分银杏酸的含量。银杏酮酯含有银杏总黄酮和萜内酯等化学成分,具有抗炎、抗氧化应激、抗血小板聚集等药理作用,在冠心病心绞痛、脑卒中、血管性痴呆等血管相关性疾病治疗上具有重要价值。笔者对银杏酮酯的物质基础、临床应用及作用机制三方面研究进行综述,重点讨论其在作用机制方面的研究进展,以期为银杏酮酯在血管相关性疾病研究提供参考。Ginkgo biloba has been widely used to treat diseases such as blood stasis blocking collaterals,chest pain,stroke,and hemiplegia.Ginkgo biloba extract 50(GBE50)is the fifth generation of Ginkgo biloba extract(GBE).The chemical components of GBE50 include total flavonoids and terpene lactones.GBE50 shows multiple pharmacological effects such as anti-inflammatory,antioxidant stress,and antiplatelet aggregation.In clinic,it has been widely used in vascular-related diseases such as coronary heart disease,angina pectoris,stroke,and vascular dementia.The authors review the studies on the material basis,clinical application,and mechanism of GBE50,and mainly focus on the research progress in pharmacological mechanism.These might provide a fresh perspective and idea for research on GBE50 in the treatment of vascular-related diseases.

关 键 词：银杏酮酯 银杏总黄酮 萜内酯 血管相关性疾病 药理作用机制 

分 类 号：R961[医药卫生—药理学]