环状RNA对神经血管单元的调控作用及其应用进展  

Advance in Role of Circular RNA on Neurovascular Units and its Application

作　　者：沈灵 姚红红[1] SHEN Ling;YAO Honghong(School of Medicine,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学医学院,南京210009

出　　处：《中国药学杂志》2024年第11期970-973,共4页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金项目资助(82025033、82230115);科技创新-2030重大项目资助(2021ZD0202904/2021ZD0202900)。

摘　　要：环状RNA(circular RNA,circRNA)是一类具有共价闭合环状结构的单链RNA分子,在疾病发生发展中具有重要作用。神经血管单元是指脑微血管细胞、胶质细胞、神经元和细胞外基质等组成的脑功能的基本结构单元,对维持大脑稳态具有重要意义,近年来已成为多种复杂脑疾病的研究热点。然而circRNA对于神经血管单元的调控作用目前尚未明确,本文就circRNA对神经血管单元的调控作用及其应用的研究进展进行综述,以期为相关疾病提供治疗新靶点和新策略。Circular RNAs(circRNAs)are a class of single-stranded RNA molecules with covalently closed continuous loops which are involved in the occurrence and development of diseases.Neurovascular units(NVU)refer to the cellular and molecular interfaces between the circulatory system and central nervous system(CNS),mainly composed of microvascular cells,glial cells,neurons,and extracellular matrix,which are of great significance for maintaining brain homeostasis.However,the role of circRNA on NVU remains unknown.This article summarizes the latest research progress,with the aim of providing new targets and strategies for the treatment of related diseases.

关 键 词：环状RNA 神经血管单元 缺血性脑卒中 抑郁症 

分 类 号：R964[医药卫生—药理学]