血清长链非编码RNA与稳定型冠心病患者PCI后冠状动脉微循环障碍及预后的关系研究  

Relationship between Serum Long Non-Coding RNA and Coronary Microcirculation Disorder and Prognosis in Patients with Stable Coronary Heart Disease after PCI

作　　者：马岩萍 伍旭升 宋磊 周鹏飞 MA Yanping;WU Xusheng;SONG Lei;ZHOU Pengfei(Department of Cardiovascular Medicine,Shanghai Medical University Hospital,Shanghai 201700,China;Department of CardiovasculaRMedicine,Shanghai Tongren Hospital,Shanghai 200336,China)

机构地区：[1]上海医大医院心血管内科,上海市201700 [2]上海市同仁医院心血管内科,200336

出　　处：《实用心脑肺血管病杂志》2024年第8期8-12,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2022年度上海市“科技创新行动计划”自然科学基金项目(22ZR1457300)。

摘　　要：目的探讨血清长链非编码RNA(LncRNA)X染色体失活特异转录物(XIST)、小核仁RNA宿主基因1(SNHG1)与稳定型冠心病患者PCI后冠状动脉微循环障碍(CMD)及预后的关系。方法选取2021年11月—2023年11月在上海医大医院行PCI的175例稳定型冠心病患者为研究对象,根据患者PCI后是否伴有CMD将其分为CMD组(n=63)和非CMD组(n=112)。收集患者一般资料、冠状动脉生理学指标〔血流储备分数(FFR)、冠状动脉血流储备(CFR)及冠状动脉微循环阻力指数(IMR)〕及血清LncRNA XIST、SNHG1。所有患者于PCI后6个月进行随访,记录其主要不良心血管事件(MACE)发生情况,若患者发生MACE则判定为预后不良。采用Pearson相关分析探讨稳定型冠心病患者PCI后IMR与血清LncRNA XIST、SNHG1的关系;稳定型冠心病患者PCI后预后不良的影响因素分析采用多因素Logistic回归分析。结果CMD组IMR、血清LncRNA XIST高于非CMD组,血清LncRNA SNHG1低于非CMD组(P<0.05)。Pearson相关分析结果显示,稳定型冠心病患者PCI后IMR与血清LncRNA XIST呈正相关(r=0.525,P<0.001),与血清LncRNA SNHG1呈负相关(r=-0.515,P<0.001)。175例患者中,预后不良61例,预后良好114例。预后不良者FFR、CFR、血清LncRNA SNHG1低于预后良好者,IMR、血清LncRNA XIST、CMD发生率高于预后良好者(P<0.05)。多因素Logistic回归分析结果显示,FFR、CFR、血清LncRNA SNHG1升高是稳定型冠心病患者PCI后预后不良的保护因素,IMR、血清LncRNA XIST升高是稳定型冠心病患者PCI后预后不良的危险因素(P<0.05)。结论血清LncRNA XIST、SNHG1与稳定型冠心病患者PCI后发生CMD相关,且血清LncRNA XIST升高是稳定型冠心病患者PCI后预后不良的危险因素,而血清LncRNA SNHG1升高是其保护因素。Objective To investigate the relationship between serum long non-coding RNA(LncRNA)X chromosome inactivation specific transcript(XIST),small nuclear RNA host gene 1(SNHG1)and coronary microcirculation disfunction(CMD)and prognosis in patients with stable coronary heart disease after PCI.Methods A total of 175 patients with stable coronary heart disease who underwent PCI in Shanghai Medical University Hospital from November 2021 to November 2023 were selected as the study subjects.According to whether patients had CMD after PCI,they were divided into CMD group(n=63)and non-CMD group(n=112).The general data,coronary physiological indexes[fractional flow reserve(FFR),coronary flow reserve(CFR)and index of microcirculatory resistance(IMR)]and serum LncRNA XIST and SNHG1 were collected.All patients were followed up at 6 months after PCI,and the occurrence of major adverse cardiovascular events(MACE)was recorded.If MACE occurred in patients,it was judged as poor prognosis.Pearson correlation analysis was used to explore the relationship between IMR and serum LncRNA XIST,SNHG1 in patients with stable coronary heart disease after PCI.Multivariate Logistic regression analysis was used to analyze the influencing factors of poor prognosis in patients with stable coronary heart disease after PCI.Results The IMR and serum LncRNA XIST in the CMD group were higher than those in the non-CMD group,and the serum LncRNA SNHG1 was lower than that in the non-CMD group(P<0.05).Pearson correlation analysis showed that IMR was positively correlated with serum LncRNA XIST in patients with stable coronary heart disease after PCI(r=0.525,P<0.001),and negatively correlated with serum LncRNA SNHG1(r=-0.515,P<0.001).Among 175 patients,61 cases had poor prognosis and 114 cases had good prognosis.CFR,FFR and serum LncRNA SNHG1 in patients with poor prognosis were lower than those in patients with good prognosis,while IMR,serum LncRNA XIST and incidence of CMD were higher than those in patients with good prognosis(P<0.05).Multivariate Logistic r

关 键 词：冠心病 经皮冠状动脉介入治疗 长链非编码RNA 冠状动脉微循环障碍 预后 

分 类 号：R541.4[医药卫生—心血管疾病]