吞咽困难患者新型口服抗肿瘤药物的替代给药方法  

Alternative Drug Delivery Methods for Novel Oral Anticancer Drugs in Patients with Dysphagia

作　　者：郭子寒 张洪禄 戴贤春 张志圣 刘继勇 王萌萌 杜琼 GUO Zihan;ZHANG Honglu;DAI Xianchun;ZHANG Zhisheng;LIU Jiyong;WANG Mengmeng;DU Qiong(Department of Pharmacy,Fudan University Shanghai Cancer Center,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Department of Pharmacy,Shanghai Proton and Heavy Ion Center,Shanghai 201315,China)

机构地区：[1]复旦大学附属肿瘤医院药剂科,上海200032 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]上海市质子重离子医院药剂科,上海201315

出　　处：《医药导报》2024年第8期1278-1285,共8页Herald of Medicine

基　　金：上海市抗癌协会“雏鹰”计划(SACA-CY21B04);上海市抗癌协会“翱翔”计划(SACA-AX202110);上海市青年药学人才能力提升项目([2023]04)。

摘　　要：目的为吞咽困难的患者提供新型口服抗肿瘤药物的替代给药方法。方法根据“新型抗肿瘤药物临床应用指导原则(2022年版)”药品目录确定检索范围,通过查阅说明书,检索PubMed、Micromedex、UpToDate等数据库获得药品临时液体制剂的制备、稳定性、储存和相关临床信息。结果70种口服抗肿瘤药物被纳入文献检索,其中33种药物有相关的文献或数据支持替代给药方法,8种在说明书中有替代给药的相关信息,其他药物的证据水平各不相同。结论大部分药物临时液体制剂的证据水平较低,医疗团队在使用说明书以外的用法时应充分考虑利弊,谨慎使用。Objective To provide alternative delivery methods of novel oral antitumor drugs for patients with dysphagia.Methods The retrieval range was determined according to the“Guidelines for Clinical Application of Novel Antitumor Drugs(2022 edition)”.By consulting the instructions and searching databases such as PubMed,Micromedex,UpToDate,etc.,the preparation,stability,storage,and related clinical information of temporary liquid drug formulations were obtained.Results Seventy novel oral anticancer drugs were included in the literature search.Thirty-three drugs had relevant literature or data supporting alternative administration methods,only eight had information on alternative administration in the instructions,and the level of evidence for other drugs varied.Conclusion The evidence levels were low for most temporary liquid formulations,and medical teams should fully consider the advantages and disadvantages of using these products outside the instructions and use them with caution.

关 键 词：新型口服抗肿瘤药物 吞咽困难 替代给药方法 

分 类 号：R979.1[医药卫生—药品]