可变形纳米囊载体——传递体在透皮制剂中的研究进展  

Research Progress on Deformable Nanocapsular Carrier-Transferosomes in Transdermal Preparations

作　　者：李梓茜 陈潇[1] 曹德英[1] 党云洁[1] LI Ziqian;CHEN Xiao;CAO Deying;DANG Yunjie(Department of Pharmacy,Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]河北医科大学药剂学教研室,石家庄050017

出　　处：《医药导报》2024年第8期1302-1308,共7页Herald of Medicine

基　　金：河北省自然科学基金资助项目(H2020206610);河北省教育厅引进留学人才项目(C20220345)。

摘　　要：透皮制剂可以有效避免首过效应,且具有良好的临床用药依从性。传递体(TF)作为一种新型的可变形类脂囊泡,具有较好的皮肤渗透效率和包封率,可在体内维持稳定的血药浓度而发挥药效,是极具开发前景的新型透皮吸收制剂。该文总结了目前TF的研究现状,包括制备工艺、评价指标及其临床应用现状,并对其研究前景予以展望。Transdermal preparations can effectively avoid the first-pass effect and have good clinical medication compliance.Transfersomes(TF),as a novel deformable lipid vesicle with good skin penetration efficiency and encapsulation rate,exert their efficacy by maintaining stable plasma concentration in vivo.They are novel transdermal absorption preparations with great development prospects.This article summarized the current research on TF,including the preparation technology,evaluation indexes,and clinical application,and prospected its research prospects.

关 键 词：经皮给药 传递体 类脂质囊泡 

分 类 号：R94[医药卫生—药剂学]