植物源黄酮类化合物对幽门螺杆菌脲酶抑制作用的研究进展  

Research Progress on the Inhibition of Helicobacter Pylori Urease by Plant-derived Flavonoids

作　　者：徐文艳 黄干荣[1] 廖丽娟 罗家锱 黄亮[1] 黄衍强[1] XU Wenyan;HUANG Ganrong;LIAO Lijuan;LUO Jiazi;HUANG Liang;HUANG Yanqiang(Youjiang Medical University for Nationalities,Guangxi Scientific and Technological Innovation Cooperation Base for Prevention and Control of Pathogenic Microorganisms Drug Resistance,Key Laboratory for Prevention and control of Drug Resistant Microbial Infection Research in University of Guangxi,Baise 533000,China)

机构地区：[1]右江民族医学院,广西病原微生物耐药防控科技创新合作基地,广西高校耐药微生物感染防治研究重点实验室,百色533000

出　　处：《医药导报》2024年第8期1309-1314,共6页Herald of Medicine

基　　金：国家自然科学基金资助项目(32060018);中央引导地方发展项目(桂科ZY20198004)。

摘　　要：脲酶作为氮循环的关键酶,为生物体提供生长所需的氮源,同时也是一种在各种致病菌中发现的毒力因子。幽门螺杆菌(H.pylori)产生的脲酶为其在胃里的定植和生存中起着重要作用,而幽门螺杆菌的感染与肠化生、活动性胃炎、消化性溃疡和胃癌等胃肠道疾病密切相关,且随着耐药性菌株的增多,迫切需要治疗有效、安全的新型药物,所以幽门螺杆菌成为最常研究的产脲酶细菌之一,脲酶作为抗菌药物的潜在靶点也受到关注。安全性较高的药用植物已被证明具有治疗潜力,许多植物天然提取物已成为新型药物开发的灵感和起点,以往研究还发现许多天然存在的黄酮类化合物具有抗脲酶活性。该文概述了一些植物源黄酮类化合物对幽门螺杆菌脲酶的抑制作用,根据其来源、结构特点以及可能的作用机制,寻找和开发植物来源且特异性抗幽门螺杆菌的化合物,从而为临床候选药物的研发提供参考。As a key enzyme in the nitrogen cycle,urease is not only a nitrogen source for the growth of organisms,but also a virulence factor found in various pathogenic bacteria.The urease produced by Helicobacter pylori(H.pylori)plays an important role in the colonization and survival of H.pylori.However,H.pylori infections are closely associated with gastrointestinal diseases such as intestinal metaplasia,active gastritis,peptic ulcer and gastric cancer.With the increasing of drug-resistant strains,there is an urgent need for effective and safe new drugs,so H.pylori has become one of the most frequently studied urease-producing bacteria.Urease has also received considerable attention as a potential target for antibacterial drugs.Medicinal plants with high safety have been proven to have therapeutic potential,and many natural plant extracts have become the inspiration and starting point of new drug development;previous studies have also found that many naturally occurring flavonoids have anti-urease activity.Therefore,this review summarizes the effects of inhibiting some plant-derived flavonoids on H.pylori urease.According to their origins,structural characteristics,and possible mechanism of action,we seek and develop plant-derived compounds with the specificity of anti-H.pylori,which can provide references for developing clinical drug candidates.

关 键 词：黄酮类化合物 幽门螺杆菌 脲酶 抗菌作用 

分 类 号：R978[医药卫生—药品]