扩张型心肌病患者地高辛中毒的药学监护  

Individualized Pharmaceutical Care for Digoxin Poisoning in Patient with Dilated Cardiomyopathy

作　　者：杨晓娟 王兰[1] 崔淑彬 冀召帅 毛乾泰 宋微微 艾超 YANG Xiaojuan;WANG Lan;CUI Shubin;JI Zhaoshuai;MAO Qiantai;SONG Weiwei;AI Chao(Department of Pharmacy,School of Clinical Medicine,Tsinghua University,Beijing 102218,China;Department of Clinical Laboratory,Beijing Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]清华大学附属北京清华长庚医院/清华大学临床医学院药学部,北京102218 [2]清华大学附属北京清华长庚医院/清华大学临床医学院检验医学科,北京102218

出　　处：《医药导报》2024年第8期1321-1325,共5页Herald of Medicine

摘　　要：目的介绍1例扩张型心肌病患者地高辛中毒的原因分析、药物治疗及药学服务,为地高辛中毒的鉴别及治疗提供药学服务思路。方法药师应用治疗药物管理分析患者住院前后药物治疗过程,结合治疗药物监测和药物基因检测,从基础疾病、基因多态性、药物剂量、联合用药、生理因素和其他病理因素多角度分析地高辛中毒原因,协助临床重整药物,优化药物治疗方案。结果临床医师采纳了临床药师的建议,患者预后良好,治疗后期未再出现地高辛中毒。结论为扩张型心肌病及其他基础疾病患者地高辛中毒提供一种切实可行的处理方案,对预防治疗地高辛中毒具有一定的借鉴意义,也为药学服务提供新思路。Objective To introduces drug treatment and individualized pharmaceutical care for a patient with dilated cardiomyopathy digoxin poisoning and provides ideas for pharmaceutical care.Methods The pharmacist used therapeutic drug management to analyze the course of drug treatment before and after hospitalization,combined with therapeutic drug monitoring and drug-gene detection,to analyze the causes of poisoning in digoxin from the perspectives of underlying diseases,polymorphism,drug dosage,combination of drugs,physiological and other pathological factors,and to assist in clinical drug reformulation and optimization of drug treatment regimens.Results The clinician accepted the clinical pharmacist's suggestion.The patient had a good prognosis,and digoxin poisoning did not occur in the later period.Conclusion This case provides a feasible treatment for dilated cardiomyopathy and other patients with digoxin intoxication;it can be used as a reference for the prevention and treatment of digoxin poisoning and provide a new direction for the development of hospital pharmaceutical care and pharmaceutical professionals.

关 键 词：地高辛 扩张型心肌病 治疗药物监测 治疗药物管理 药学监护 

分 类 号：R963[医药卫生—微生物与生化药学]