不育男性精液质量和生殖激素与脂肪因子的相关性分析  

Analysis of the correlation between the semen quality of infertile men and their reproductive hormone and adipokines levels

作　　者：王生玉 谢宜昌 马婧 赵邦荣 王树松 WANG Shengyu;XIE Yichang;MA Jing;ZHAO Bangrong;WANG Shusong(Qinghe County Central Hospital,Qinghe,Hebei Province,054800;Hebei Reproductive Health Hospital,Hebei Key Laboratory of Reproductive Medicine,Shijiazhuang)

机构地区：[1]河北省清河县中心医院,054800 [2]河北省生殖健康医院,河北省生殖医学重点实验室

出　　处：《中国计划生育学杂志》2024年第7期1613-1617,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨不育男性的精液质量和生殖激素与脂肪因子的关系。方法:选择不育男性155名,其中体重正常组(BMI<24 kg/m^(2))53例、超重组(24 kg/m^(2)≤BMI<28 kg/m^(2))53例和肥胖组(BMI≥28 kg/m^(2))49例。CASA检测精液参数,化学发光免疫分析方法测定血清生殖激素,ELISA检测血清、精浆脂肪因子瘦素(LEP)、脂联素(ADPN)和锌α2糖蛋白(ZAG)含量。分析男性精液参数、生殖激素与血液、精浆中脂肪因子的相关性。结果:与正常组相比,肥胖组男性精液量(t=-3.239;P=0.002)和精子活力明显降低(t=-3.449;P=0.001);血清睾酮水平(t=-5.522;P<0.001)和ZAG水平(t=-3-354;P=0.001)均明显降低;155名不育男性精浆ADPN与BMI呈负相关(r=-0.160;P<0.05),与精液量、精子浓度、精子总数呈正相关(r=0.250,r=0.250,r=0.368;P<0.05),精浆ZAG与BMI、精子浓度、精子总数呈负相关(r=-0.254,r=-0.213,r=-0.178;P<0.05)。精浆与血液脂肪因子间无相关性。结论:肥胖可影响男性血清睾酮和精液质量,不育男性精浆ADPN和ZAG与精液质量密切相关。Objective: To investigate the correlation between the semen quality of infertile men and their reproductive hormone and adipokines levels. Methods: 155 infertile men were selected in this study, including 53 cases with BMI<24 kg/m^(2) in group A, 53 cases with 24≤BMI<28 kg/m^(2) in group B and 49 cases with BMI≥28 kg/m^(2) in group C. CASA was used to measure the semen parameters of these infertile men. Chemiluminescent immunoassay was used to determine the serum reproductive hormones levels, and ELISA was used to measure the levels of the serum and plasma adipokine leptin(LEP), lipocalin(ADPN) and zinc α2 glycoproteins(ZAG) of the infertile men. The correlation between the semen parameters and the reproductive hormones levels of the infertile men and their serum and plasma LEP levels was analyzed. Results: The semen volume(t=-3.239, P=0.002), the sperm motility(t=-3.449, P=0.001), the serum testosterone level(t=-5.522, P<0.001) and the ZAG level(t=-3.354, P=0.001) of the infertile men in group B were significantly lower than those of the infertile men in group A. The seminal plasma ADPN level of the 155 infertile men was negative correlation with their BMI value(r=-0.160, P<0.05), but which was positively correlated with their semen volume, sperm concentration and total sperm count(r=0.250, r=0.250, r=0.368, P<0.05). The seminal plasma ZAG level of the infertile men was negatively correlated with their BMI value, sperm concentration and total sperm count(r=-0.254, r=-0.213, r=-0.178, P<0.05). There was no correlation between the seminal adipokines level of the infertile men and their blood adipokines level. Conclusion: Obesity can affect the serum testosterone level and semen quality of the infertile men. The seminal ADPN and ZAG levels of the infertile men are closely related to their semen quality.

关 键 词：男性不育 肥胖 精液参数 脂质代谢 脂肪因子 

分 类 号：R698.2[医药卫生—泌尿科学]