HDP患者外周血Hb、Fib、D-D及LMR评估病情程度和不良妊娠结局价值  

Value of the levels of hemoglobin, D-dimer and fibrinogen in peripheral blood, and lymphocyte/monocyte ratiovalue of pregnant women with pregnancy-induced hypertension (PIH) for predicting their severity of PIH and adverse pregnancy outcomes

作　　者：吴玉雯 许海娟 吴玮 WU Yuwen;XU Haijuan;WU Wei(Huangshan People's Hospital,Huangshan,Anhui Province,245000)

机构地区：[1]安徽省黄山市人民医院,245000

出　　处：《中国计划生育学杂志》2024年第7期1644-1647,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨外周血血红蛋白(Hb)、D-二聚体(D-D)、纤维蛋白原(Fib)和淋巴细胞数/单核细胞数比值(LMR)对妊娠期高血压疾病(HDP)病情程度和不良妊娠结局的预测价值。方法:回顾性收集2019年7月-2022年9月本院就诊的107例HDP孕妇为病例组,根据病情程度分为妊娠期高血压组30例、轻度子痫前期组40例、重度子痫前期组37例,同期产前检查并分娩的50例健康孕妇为对照组,分析各组血Hb, Fib、D-D、LMR等指标差异,受试者工作特征(ROC)曲线分析各指标预测HDP不良妊娠价值。结果:病例组Hb、Fib、D二聚体水平及LMR均高于对照组,且随着HDP病情程度加重各指标水平升高(均P<0.05);Spearman相关性分析,HDP患者Fib、Hb、D二聚体、LMR水平与其疾病严重程度存在正相关(r=0.426、0.528、0.388、0.719,均P<0.05);随着病情程度加重不良妊娠结局发生率升高(P<0.05)。ROC曲线分析,HDP患者血Hb、Fib、D-D及LMR及4项联合应用评估HDP患者不良妊娠结局的曲线下面积分别为0.811、0.890,0.711、0.633、0.951。结论:HDP患者血Fib、Hb、D-D、LMR水平与疾病严重程度正相关,且会对妊娠结局产生不良影响,联合检测评估不良妊娠结局有一定临床价值。Objective:To explore the value of the levels of hemoglobin(Hb),D-dimer(D-D) and fibrinogen(Fib)in peripheral blood,and lymphocyte/monocyte ratio(LMR) value of pregnant women with hypertensive disorder complicating pregnancy(PIH) for predicting their severity of PIH and adverse pregnancy outcomes.Methods:107 pregnant women with PIH from July 2019 to September 2022 were collected in study group retrospectively,including 30 women with gestational hypertension in group A,40 women with mild preeclampsia in group B and 37 women with severe preeclampsia in group C.In addition,50 healthy pregnant women who underwent physical examinations during the same period were selected in control group.The differences of the levels of Hb,Fig and D-D,and the LMR value of the women in these groups were analyzed.Receiver operating characteristic(ROC) curve was used to analyze the value of the levels of Hb,Fig and D-D,and the LMR value of the women with PIH for predicting their adverse pregnancy outcomes.Results:The levels of Hb,Fib and D-D, and the LMR value of the women in the study group were significantly higher than those of the women in the control group,and which of the women in group A,in group B and in group C had increased gradually(all P<0.05).Spearman correlation analysis showed that the levels of Hb,Fib and D-D,and the LMR value of the women with PIH were positively correlated with the severity of their PIH(r=0.426,0.528,0.3.88,0.719,all P<0.05).The incidence of the adverse pregnancy outcomes of the women with PIH increased with the severity of their PIH(P<0.05).ROC curve analysis showed that the areas under the curve of the Hb level,the Fib level,the D-D level,the LMR value,and the combined levels of Hb,Fib and D-D,and the LMR value of the women with PIH for evaluating their adverse pregnancy outcomes were 0.811,0.890,0.711,0.633 and 0.951,respectively.Conclusion:The levels of Hb,Fib and D-D,and the LMR value of the women with PIH are positively correlated with the severity of their PIH,and which have adverse effects on th

关 键 词：妊娠期高血压疾病 病情程度 血红蛋白 淋巴细胞数和单核细胞数比值 D-二聚体 纤维蛋白原 相关性 不良妊娠结局 评估 

分 类 号：R714.246[医药卫生—妇产科学]