孕妇宫颈分泌物中胎盘α1-微球蛋白、胎儿纤维连接蛋白水平预测自发性早产价值  

Predictive value of the levels of placental alpha 1-microglobulin and fetal fibronectin in the cervical discharge of pregnant women for their spontaneous preterm labor

作　　者：杨姗姗 孙桂霞 张艳夏 YANG Shanshan;SUN Guixia;ZHANG Yanxia(Shanxi Provincial Children's Hospital(Shanxi Maternaland Child Health Care Hospital),Taiyuan,Shanxi Province,030006)

机构地区：[1]山西省儿童医院,山西省妇幼保健院,太原030006

出　　处：《中国计划生育学杂志》2024年第7期1653-1657,共5页Chinese Journal of Family Planning

摘　　要：目的:探究宫颈分泌物中胎盘α1-微球蛋白(PAMG-1)和胎儿纤维连接蛋白(fFN)水平对自发性早产的预测价值。方法:收集2021年4月-2023年4月本院收治的128例发生自发性早产患者临床资料纳入早产组,同期产前检查并足月分娩的正常孕妇128例临床资料纳入正常组。比较两组临床资料,宫颈分泌物PAMG-1、fFN水平;采用受试者工作曲线(ROC)分析PAMG-1、fFN对孕妇发生自发性早产的预测价值。结果:PAMG-1、fFN对孕妇发生自发性早产的预测准确性分别为68.0%和67.6%、阳性预测值分别为76.1%和73.2%、阴性预测值分别为63.7%和64.2%,2项联合预测的准确性(69.9%)和阳性预测值(79.3%)提高(P<0.05);经ROC曲线分析,PAMG-1、fFN预测孕妇发生自发性早产的曲线下面积分别为0.680和0.679,灵敏度分别为52.3%、55.5%,特异度分别为83.6%、79.7%,2项联合预测的曲线下面积为0.699,灵敏度53.9%、特异度85.9%。结论:PAMG-1、fFN可作为孕妇发生自发生性早产的预测指标,且2项联合可提高预测效能。Objective:To evaluate the predictive value of the levels of placental alpha 1-microglobulin(PAMG-1) and fetal fibronectin(fFN) in the cervical discharge of pregnant women for their spontaneous preterm labor.Methods:The clinical data of 128 pregnant women with spontaneous preterm labor(in study group) from April 2021 to April 2023were collected,and another 128 normal pregnant women who underwent antenatal examination and delivered at full term were included in control group during the same period.The clinical data and the levels of PAMG-1 and fFN in the cervical discharge of the women were compared between the two groups.Receiver operating characteristic(ROC) curve was used to analyze the predictive value of the PAMG-1 and fFN levels of the pregnant women for their spontaneous preterm labor.Results:The predictive accuracy,the positive predictive value and the negative predictive value of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 68.0%,76.1 % and 63.7%,respectively,and which of the fFN level of the women for predicting their spontaneous preterm labor were 67.6%,73.2%and 64.2%,respectively.The accuracy and the positive predictive value of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 69.9% and 79.3%,and which were significantly higher than those of the PAMG-1 level and the fFN level(P<0.05).ROC curve analysis showed that the area under the curve,the sensitivity and the specificity of the PAMG-1 level of the women for predicting their spontaneous preterm labor were 0.680,52.3% and 83.6%,respectively,which of the fFN level of the women for predicting their spontaneous preterm labor were 0.679,55.5% and 79.7%,respectively,and which of the combined PAMG-1 and fFN levels of the women for predicting their spontaneous preterm labor were 0.699,53.9% and 85.9%,respectively.Conclusion:The PAMG-1 and fFN levels in the cervical discharge of the pregnant women can be used as the predictors for their spontaneous preterm labor,and the com

关 键 词：自发性早产 宫颈分泌物 胎盘α1-微球蛋白 胎儿纤维连接蛋白 预测价值 

分 类 号：R714.21[医药卫生—妇产科学]