O型血孕妇产前血清IgG抗A(B)抗体效价积分评估HDN发生价值  

Value of the prenatal serum immunoglobulin G Anti A (B) antibody titer score of pregnant women with type O blood for evaluating the occurrence of the hemolytic disease of their newborn

作　　者：何烁晴 洪立闩 吴永美 孙月娥 HE Shuoqing;HONG Lishuan;WU Yongmei;SUN Yue’e(Hefei Eighth People's Hospital,Hefei,Anhui Province,238000)

机构地区：[1]安徽省合肥市第八人民医院,238000

出　　处：《中国计划生育学杂志》2024年第7期1687-1691,共5页Chinese Journal of Family Planning

摘　　要：目的:探究产前O型血孕妇血清中免疫球蛋白G(IgG)抗A(B)抗体效价积分对新生儿溶血(HDN)发生的预测价值。方法:回顾性选取2022年1月-2023年12月本院收治的101例O型血孕妇临床资料,根据新生儿是否发生HDN分为为HDN组(n=26)和非HDN组(n=75)。比较两组临床资料、产前血清中IgG抗A(B)抗体效价积分等。采用Spreaman相关分析分析孕妇血清中IgG抗A(B)抗体效价积分与HDN发生的相关性,受试者工作曲线(ROC)分析O型血孕妇血清中IgG抗A(B)抗体效价积分对HDN发生的预测价值。结果:HDN组孕妇产前血清IgG抗A(B)抗体效价均高于非HDN组,当产前血清的IgG抗A(B)抗体效价相同时,HDN组孕妇的血清IgG抗A(B)抗体效价积分明显于非HDN组(均P<0.05);Spearman相关分析,孕妇产前血清IgG抗A(B)抗体效价积分与HDN发生呈正相关(r=0.666,P<0.001);ROC曲线分析,O型血孕妇血清中IgG抗A(B)抗体效价积分预测HDN发生曲线下面积0.874,截断值54.88,灵敏度84.0%、特异度94.7%。结论:产前O型血孕妇血清中IgG抗A(B)抗体效价积分新生儿发生HDN概率呈正相关,且对HDN的发生有一定预测价值。Objective:To explore the value of the prenatal serum immunoglobulin G(IgG) Anti A(B) antibody titer score of pregnant women with type O blood for evaluating the occurrence of the hemolytic disease of their newborn(HDN).Methods:The clinical data of 101 pregnant women with type O blood who had admitted to the hospital from January 2022 to December 2023 were selected retrospectively,and these women were divided into group A(26 women with HDN) and group B(75 women without HDN) according to the presence or absence of their HDN.The clinical data and the prenatal titer score of the serum IgG anti-A(B) antibody of the women were compared between the two groups.Spreaman correlation analysis was utilized to discuss the correlation between the prenatal titer score of the serum IgG anti-A(B) antibody of the pregnant women and the occurrence of their HDN.The predictive value of the prenatal titer score of the serum IgG anti-A(B) antibody of the women with type O blood for predicting the occurrence of their HDN was evaluated by receiver operating characteristic(ROC) curve.Results:The prenatal serum IgG anti-A(B) antibody titer of the women in group A was significantly higher than that of the women in group B.When the prenatal serum IgG anti-A(B) antibody titer of the women in the two groups was the same,the serum IgG anti-A(B)antibody titer score of the women in group A was significantly higher than that of the women in group B(all P<0.05).Spearman correlation analysis showed that the prenatal serum IgG anti-A(B) antibody titer score of the women with type O blood was positively correlated with the occurrence of their HDN(r=0.666,P<0.001).ROC curve analysis showed that the area under curve,the cutoff value,the sensitivity and the specificity of the prenatal serum IgG anti-A(B) antibody titer score of the women with type O blood for predicting the occurrence of their HDN were 0.874,54.88,94.7 % and 84.0%,respectively.Conclusion:The prenatal serum IgG anti-A(B) antibody titer score of the women with type O blood is positive corr

关 键 词：O型血孕妇 血清IgG抗A(B)抗体效价 效价积分 新生儿溶血症 临床评估 

分 类 号：R722.18[医药卫生—儿科] R446.6[医药卫生—临床医学]