妊娠期念珠菌性阴道炎的孕期检测在早产预测中的价值  

Value of pregnancy detection of candida vaginitis in the preterm delivery prediction

作　　者：张社玲 熊利敏 王华 Zhang Sheling;Xiong Limin;Wang Hua(Department of Medical Laboratory,Xunxian People’s Hospital,Xunxian,Henan 456250,China)

机构地区：[1]浚县人民医院医学检验科,河南浚县456250

出　　处：《感染、炎症、修复》2024年第2期114-118,共5页Infection Inflammation Repair

摘　　要：目的:探讨妊娠期念珠菌性阴道炎的孕期检测在早产预测中的应用价值。方法:选取浚县人民医院2020年1月至2023年1月期间收治的85例妊娠期念珠菌性阴道炎孕妇,均接受阴道分泌物检查,根据分娩孕周分为早产组和非早产组,收集两组一般资料、阴道分泌物实验室检查指标、阴道微生态状况,采用多因素Logistic回归分析方法分析影响妊娠结局的因素,绘制受试者工作特征曲线(ROC曲线)并计算ROC曲线下面积(AUC),分析阴道分泌物和阴道微生态检查对早产的预测价值。结果:早产组43例,非早产组37例;多因素Logistic回归分析显示,宫颈管长度(OR=0.001,95%CI=0.000-0.052)为产妇早产保护因素,胎儿纤连蛋白(FFN,OR=1.054,95%CI 1.007-1.104)、C反应蛋白(CRP,OR=1.321,95%CI 1.057-1.651)、乳酸杆菌含量少(OR=31.688,95%CI 2.860-351.114)为产妇早产危险因素(P<0.05);ROC曲线分析,宫颈管长度(AUC=0.889,95%CI 0.799-0.949,敏感度90.70%、特异度73.00%)、CRP(AUC=0.703,95%CI 0.590-0.800,敏感度95.35%,特异度37.84%)、FFN(AUC=0.706,95%CI 0.593-0.802,敏感度51.16%,特异度86.49%)、乳酸杆菌含量少(AUC=0.544,95%CI 0.429-0.656,敏感度79.07%,特异度29.73%)为妊娠期念珠菌性阴道炎孕产妇早产预测因子。结论:通过阴道分泌物和阴道微生态检测及时诊断、治疗妊娠期念珠菌性阴道炎非常重要,与是否造成早产密切相关。宫颈管长度、FFN、CRP、乳酸杆菌含量对早产具有良好的预测价值。Objective:To investigate application value of the detection of candida vaginitis during pregnancy in predicting preterm delivery.Methods:A total of 85 pregnant women with candida vaginitis admitted to Xunxian People’s Hospital from January 2020 to January 2023 were selected to receive vaginal secretions examination.They were divided into preterm and non-preterm according to their gestational weeks.General data,laboratory test indicators of vaginal secretions and vaginal microecology of the two groups were collected.Multivariate Logistic regression was used to analyze the factors affecting pregnancy outcome,receiver operating characteristic curve(ROC curve)was drawn and areas under the ROC curve(AUC)was calculated.The predictive value of vaginal secretions and vaginal microecological examination for premature birth was analyzed.Results:For premature delivery group(n=43)and non-premature delivery group(n=37),multivariate logistic regression analysis showed that the length of cervical canal(OR=0.001,95%CI=0.000-0.052)was the protective factor for premature delivery,and(FFN,OR=1.054,95%CI 1.007-1.104),C-reactive protein(CRP,OR=1.321,95%CI 1.057-1.651),low lactobacillus content(OR=31.688,95%CI 2.860-351.114)were the protective factors for premature delivery(P<0.05).ROC curve analysis,cervical canal length(AUC=0.889,95%CI 0.799-0.949,sensitivity 90.70%,specificity 73.00%),CRP(AUC=0.703,95%CI 0.590-0.800,sensitivity 95.35%,specificity 37.84%),FNN(AUC=0.706,95%CI 0.593-0.802,sensitivity 51.16%,specificity 86.49%),low lactobacillus content(AUC=0.544,95%CI 0.429-0.656,sensitivity 79.07%,specificity 29.73%)were the predictors of premature delivery in pregnant women with candidal vaginitis.Conclusions:It is very important to diagnose and treat candida vaginitis in time through vaginal secretions and vaginal microecological detection,which is closely related to whether it causes premature birth.Cervical canal length,FFN,CRP and lactobacillus content have good predictive value for premature delivery.

关 键 词：妊娠 念珠菌性阴道炎 阴道分泌物 阴道微生态 早产 

分 类 号：R711[医药卫生—妇产科学] R714[医药卫生—临床医学]