血清FGF-23、SOST、VCAM-1水平与尿毒症血液透析患者血管钙化的相关性分析  

Correlation of serum levels of FGF-23,SOST and VCAM-1 with vascular calcification in patients undergoing hemodialysis for uremia

作　　者：李红莉[1] 贾红红 Li Hongli;Jia Honghong(Department of Nephrology,Yan’an People’s Hospital,Yan’an 716000,China)

机构地区：[1]延安市人民医院肾内科,延安716000

出　　处：《中国实用医刊》2024年第8期33-37,共5页Chinese Journal of Practical Medicine

基　　金：延安大学附属医院科学技术研究发展计划项目(2022PT-17)。

摘　　要：目的分析血清成纤维细胞生长因子-23(FGF-23)、骨硬化蛋白(SOST)、血管细胞粘附分子-1(VCAM-1)水平与尿毒症血液透析患者血管钙化的相关性。方法病例对照研究。抽取2019年3月至2023年7月延安市人民医院收治的行血液透析治疗的尿毒症患者82例为研究组,其中血管钙化评分≥3分者36例,血管钙化评分<3分者46例。另抽取同期健康体检者82例为对照组。比较两组血清FGF-23、VCAM-1、SOST水平,比较研究组中不同血管钙化评分者的一般资料及上述三项血清指标水平,采用Pearson分析血清FGF-23、VCAM-1、SOST与血管钙化的相关性,采用Logistic分析研究血管钙化的影响因素。应用曲线下面积(AUC)分析血清FGF-23、VCAM-1、SOST水平对血管钙化的预测效能。结果研究组血清FGF-23、VCAM-1水平高于对照组,SOST水平低于对照组(P<0.05)。研究组中血管钙化评分≥3分者收缩压、舒张压、血液透析时间、透析超滤量、FGF-23水平、VCAM-1水平高于血管钙化评分<3分者,SOST水平低于血管钙化评分<3分者(P<0.05)。尿毒症血液透析患者入院时血清FGF-23、VCAM-1水平与血管钙化评分呈正相关,SOST水平与血管钙化评分呈负相关(P<0.05)。FGF-23、SOST、VCAM-1是血管钙化的影响因素(P<0.05)。入院时血清FGF-23、SOST、VCAM-1联合检测预测血管钙化的AUC为0.84,敏感度为80.56%,特异度为89.13%。结论血清FGF-23、SOST、VCAM-1水平与尿毒症血液透析患者血管钙化密切相关,可作为临床预测血管钙化程度的重要指标。Objective To analyze the correlation of serum levels of fibroblast growth factor-23(FGF-23),sclerostin(SOST)and vascular cell adhesion molecule-1(VCAM-1)with vascular calcification in patients undergoing hemodialysis for uremia.Methods This study was a case-control study.A total of 82 patients who underwent hemodialysis for uremia in Yan’an People’s Hospital from March 2019 to July 2023 were selected as the study group,including 36 cases with vascular calcification score≥3 and 46 cases with vascular calcification score<3.In addition,82 people who underwent physical examinations in the same period were selected as the control group.The serum levels of FGF-23,VCAM-1 and SOST in the two groups were compared;the general data and the levels of the above three serum indexes of patients with different vascular calcification scorers in the study group were compared.Pearson analysis was used to analyze the correlation of serum FGF-23,VCAM-1 and SOST with vascular calcification;and the influencing factors of vascular calcification were analyzed by logistic analysis.The area under the curve(AUC)was used to analyze the predictive efficacy of serum FGF-23,VCAM-1 and SOST for vascular calcification.Results The levels of serum FGF-23 and VCAM-1 in the study group were higher than those in the control group,and the level of SOST in the study group was lower than that in the control group(P<0.05).In the study group,the systolic blood pressure,diastolic blood pressure,hemodialysis time,dialysis ultrafiltration volume,level of FGF-23,and level of VCAM-1 in patients with vascular calcification score≥3 were higher,and the SOST level was lower compared with patients with vascular calcification score<3(P<0.05).The levels of serum FGF-23 and VCAM-1 at admission were positively correlated with the score of vascular calcification,and the level of SOST was negatively correlated with the score of vascular calcification in patient with hemodialysis for uremia(P<0.05).FGF-23,SOST and VCAM-1 were the influencing factors of vascular cal

关 键 词：成纤维细胞生长因子-23 骨硬化蛋白 血管细胞粘附分子-1 尿毒症 血液透析 

分 类 号：R692.5[医药卫生—泌尿科学]