地尔硫[艹卓]联合尼可地尔治疗冠心病不稳定型心绞痛的疗效及对心肌纤维化、心功能的影响  

Efficacy of diltiazem combined with nicordil in the treatment of coronary heart disease complicated by unstable angina pectoris and its influence on myocardial fibrosis and cardiac function

作　　者：姜艳艳[1] 王宁勃 Jiang Yanyan;Wang Ningbo(Department of Cardiology,Sun Simiao Hospital of Beijing University of Chinese Medicine,Tongchuan 727100,China)

机构地区：[1]北京中医药大学孙思邈医院心内科,铜川727100

出　　处：《中国实用医刊》2024年第8期93-96,共4页Chinese Journal of Practical Medicine

摘　　要：目的探讨地尔硫[艹卓]联合尼可地尔治疗冠心病不稳定型心绞痛的效果及对心功能、心肌纤维化的影响。方法前瞻性抽取2021年10月至2023年7月北京中医药大学孙思邈医院收治的180例冠心病不稳定型心绞痛患者为研究对象,按随机数字表法分为对照组和研究组,每组90例。对照组予以尼可地尔治疗,研究组在对照组基础上联合地尔硫[艹卓]治疗。比较两组疗效、治疗前后心功能[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)]、治疗后心绞痛发作次数及持续时间、心肌纤维化指标[Ⅰ型胶原蛋白(Col-Ⅰ)、Ⅲ型胶原蛋白(Col-Ⅲ)、转化生长因子β1(TGF-β1)]及不良反应发生情况。结果研究组总有效率(94.44%,85/90)高于对照组(85.56%,77/90),P<0.05;治疗后,研究组LVEF高于对照组,LVEDD、Col-I、TGF-β1、Col-Ⅲ、LVESD均低于对照组(P<0.05),心绞痛持续时间、发作次数少于对照组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论地尔硫[艹卓]与尼可地尔联合应用于治疗冠心病不稳定型心绞痛,可有效缓解患者临床症状,减轻心肌纤维化,改善心功能,效果安全可靠。Objective To investigate the effects of diltiazem combined with nicordil in the treatment of coronary heart disease complicated by unstable angina pectoris,and its influence on myocardial fibrosis and cardiac function.Methods A total of 180 patients with unstable angina pectoris caused by coronary heart disease treated in Sun Simiao Hospital of Beijing University of Chinese Medicine from October 2021 to July 2023 were prospectively selected as research objects.And they were divided into a control group and a study group using a random number table method,with 90 cases in each group.The control group was treated with nicordil,the study group was treated with diltiazem based on the treatment of the control group.The efficacy,preoperative and postoperative cardiac function evaluated by left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)and left ventricular end-systolic diameter(LVESD),frequency and duration of angina pectoris attacks,myocardial fibrosis indexes,including type I collagen(Col-I),type III collagen(Col-III)and transforming growth factor-β1(TGF-β1),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the study group(94.44%,85/90)was higher than that of the control group(85.56%,77/90),P<0.05.After treatment,the LVEF in the study group was higher,while LVEDD,Col-I,TGF-β1,Col-III and LVESD in the study group were lower compared with the control group(all P<0.05).Moreover,the duration and frequency of angina pectoris in the study group were less than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Diltiazem combined with nicordil can effectively relieve clinical symptoms,alleviate myocardial fibrosis and improve cardiac function in patients with coronary heart disease complicated by unstable angina pectoris.The effect is safe and reliable.

关 键 词：地尔硫[艹卓] 不稳定型心绞痛 尼可地尔 冠心病 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]