羟基化多壁碳纳米管固相萃取-液相色谱-串联质谱法测定儿童面霜中13种内分泌干扰物迁移量  

Determination of the Migration of Endocrine Disruptors from Children’s Face Cream by Hydroxylated Multi-walled Carbon Nanotubes Solid Phase Extraction Combined with Liquid Chromatography-Tandem Mass Spectrometry

作　　者：曹慧 张慧 王瑾 杨春 CAO Hui;ZHANG Hui;WANG Jin;YANG Chun(Zhejiang Institute of Product Quality and Safety Science,Hangzhou 310013;School of Biological and Chemical Engineering,Zhejiang University of Science&Technology,Hangzhou 310023)

机构地区：[1]浙江省产品质量安全科学研究院,浙江杭州310013 [2]浙江科技大学生物与化学工程学院,浙江杭州310023

出　　处：《分析科学学报》2024年第3期344-349,共6页Journal of Analytical Science

基　　金：浙江省市场监督管理局NQI项目(No.20210101);浙江省市场监督管理局科技项目(No.ZD2024003)。

摘　　要：建立了测定儿童面霜中13种内分泌干扰物迁移量的分析方法。样品经氨水/乙腈溶液(1∶9,V/V)超声提取,提取液稀释后经羟基化多壁碳纳米管固相萃取柱富集和净化,采用液相色谱-串联质谱负离子模式进行分析,基质外标法定量。在最优实验条件下,13种内分泌干扰物在各自的质量浓度范围内线性关系良好,相关系数(r)为0.9915~0.9996,检出限为0.3~1.5μg/kg,定量限为1.0~5.0μg/kg,在高、中、低3个加标水平下,13种内分泌干扰物的加标回收率为81.5%~109.4%,相对标准偏差为1.9%~9.2%。该方法操作简单、选择性好、检出限低,适用于儿童面霜中内分泌干扰物迁移量的测定。A method for determination of the migration of 13 endocrine disruptors in children’s face cream was developed.The sample was extracted with ammonia and acetonitrile(1∶9,V/V),purified by hydroxylated multi-walled carbon nanotubes solid phase extraction,then detected by liquid chromatography-tandem mass spectrometry in negative electrospray ionization mode,and quantified by matrix external standard method.Under the optimal experimental conditions,the linear correlation coefficients of 13 endocrine disruptors were 0.9915-0.9996,the detection limits were 0.3-1.5μg/kg,and the limits of quantification were 1.0-5.0μg/kg.The recoveries were 81.5%-109.4%with the relative standard deviations of 1.9%-9.2%at three spiked levels.The method is convenient,selective and sensitive,and can be used for the determination of endocrine disruptors in children’s face cream.

关 键 词：羟基化多壁碳纳米管 液相色谱-串联质谱 内分泌干扰物 迁移量 面霜 

分 类 号：O657.63[理学—分析化学]