脑-肠轴与阿尔茨海默病及中医药研究进展  

Alzheimer′s Disease and Traditional Chinese Medicine Research from Perspective of Gut-brain Axis

作　　者：朱少炳 曲阳 张力文 张思琪 马帅[1] 李高岩 张淼 ZHU Shaobing;QU Yang;ZHANG Liwen;ZHANG Siqi;MA Shuai;LI Gaoyan;ZHANG Miao(Heilongjiang University of Chinese Medicine,Harbin 150001,China;No.10 Acupuncture and Moxibustion Room,The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150001 [2]黑龙江中医药大学附属第二医院针灸十诊室,哈尔滨150001

出　　处：《世界中医药》2024年第11期1686-1692,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(82174509)——基于PI3K-AKT-MTOR信号通路调控细胞自噬探讨头穴丛刺抗阿尔茨海默病tau蛋白的作用机制;黑龙江博士后科研启动资金项目(LBH-Q18123)——基于督脉理论针刺对Aβ诱导的大鼠学习记忆相关机制研究;黑龙江中医药大学优秀创新人才支持计划项目(051824);黑龙江中医药大学创新科研基金项目(2020yjscx044)。

摘　　要：作为神经退行性最常见的疾病,阿尔茨海默病(AD)已经成为全世界主要的公共卫生问题之一,受到越来越多的关注。目前关于AD的治疗没有一种治愈性的方法,主要是以改善症状、延缓进程以及预防为主。研究发现大脑和肠道之间具有高度双向交流性,神经内分泌和神经系统均受到微生物显著影响,从而调节大脑功能和个体行为,所以脑-肠轴的双向调控在神经科学领域的关注度越来越高。诸多证据表明脑-肠轴参与AD的发生发展,影响AD的诸多方面。中医药对于AD的研究也不断取得新进展。As the most common disease of neurodegeneration,Alzheimer′s disease(AD)has become one of the major public health problems in the world and has received more and more attention.At present,there is no method to cure AD,and existing methods mainly focus on improving symptoms,delaying the process,and prevention.Studies have found that there is a high degree of bidirectional communication between the brain and the intestine,and both the neuroendocrine and nervous systems are significantly affected by microorganisms,thereby regulating brain function and individual behavior.Therefore,the bidirectional regulation of the gut-brain axis is attracting more and more attention in the field of neuroscience.A lot of evidence has shown that the gut-brain axis is involved in the development of AD and affects many aspects of AD.The traditional Chinese medicine(TCM)research on AD has also made new progress.

关 键 词：脑-肠轴 阿尔茨海默病 中医药 综述 研究进展 肠道菌群 病理机制 治疗作用 

分 类 号：R277.7[医药卫生—中医学]