2013-2022年湖南省梅毒扩大筛查与病例报告间关联性分析  

Correlation between expanded syphilis screening and reported cases in Hunan Province from 2013 to 2022

作　　者：张静航 周艳君 陈洁 刘维 郑军[1] 陈曦[1] 贺健梅[1] ZHANG Jinghang;ZHOU Yanjun;CHEN Jie;LIU Wei;ZHENG Jun;CHEN Xi;HE Jianmei(Hunan Provincial Center for Diseases Control and Prevention,Changsha 410005,Hunan,China)

机构地区：[1]湖南省疾病预防控制中心,长沙410005

出　　处：《中国艾滋病性病》2024年第6期641-645,共5页Chinese Journal of Aids & STD

基　　金：湖南省疾病预防控制中心“青荷”青年培育基金项目(QHJJ2023019)。

摘　　要：目的 了解2013-2022年湖南省梅毒扩大筛查现况,分析扩大筛查与病例报告之间的关联,为梅毒防控工作提供数据支撑。方法 使用平均年度变化百分比(AAPC)对扩大筛查资料及病例报告资料进行描述,使用Pearson相关分析进行二者关联性研究。结果 2013-2022年湖南省梅毒血清学筛查数呈上升趋势(AAPC=29.07%,95%CI:15.91%~43.73%,P<0.001),筛查双阳数呈上升趋势(AAPC=21.26%,95%CI:10.38%~33.22%,P<0.001),筛查双阳率呈下降趋势(AAPC=-6.71%,95%CI:-8.83%~-4.54%,P<0.001)。非监测点对血清学筛查数的贡献率为90.20%,一般人群对血清学筛查数的贡献率为94.77%。血清学筛查数与梅毒病例报告数(r=0.80,P=0.006)、隐性梅毒病例报告数(r=0.88,P<0.001)呈正相关,与早期显性梅毒病例报告数呈负相关(r=-0.93,P<0.001)。结论 湖南省梅毒血清学筛查数的上升主要是由非监测点、一般人群的血清学筛查数上升所致,梅毒病例报告数的上升与扩大筛查策略密切相关,在进行疫情研判时应使用早期显性梅毒反映梅毒发病趋势。Objective To analyze the current status of expanded syphilis screening and its correlation between reported cases in Hunan Province from 2013 to 2022,so as to provide a scientific basis for the prevention and control of syphilis.Methods Average annual percent change(AAPC)was used to describe the expanded screening data and reported cases.Pearson correlation analysis was performed on the correlation between the two.Results From 2013 to 2022,the number of serological screening for syphilis in Hunan Province showed an upward trend(AAPC=29.07%,95%CI:15.91%-43.73%,P<0.001),the number of double-positive screenings showed an upward trend(AAPC=21.26%,95%CI:10.38%-33.22%,P<0.001),and the double-positive rate showed a downward trend(AAPC=-6.71%,95%CI:-8.83%--4.54%,P<0.001).Non-monitoring sites contributed 90.20%to the growth of serological screenings,and the general population contributed 94.77%to the growth of serological screenings.The number of serological screenings was positively correlated with the reported syphilis cases(r=0.80,P=0.006)and latent syphilis cases(r=0.88,P<0.001),and negatively correlated with the reported early dominant syphilis cases(r=-0.93,P<0.001).Conclusions The increase in the number of serological screenings for syphilis in Hunan Province is mainly related to the increase in serological screening at non-monitoring sites and among the general population.The increase in reported syphilis cases is closely related to the expanded screening strategy.It is necessary to use early dominant syphilis to reflect the trend of syphilis incidence when conducting epidemic assessments.

关 键 词：梅毒 扩大筛查 病例报告 相关分析 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]