天然化合物抗HIV作用机制的研究进展  

Research progress on the mechanism of natural compounds in anti-HIV activity

作　　者：李玉杰 徐芙蓉 岳静宇[1,2,3] 孟鹏飞 马秀霞[1,2,3] 张柳婧 徐立然[1,2,3,4] LI Yujie;XU Furong;YUE Jingyu;MENG Pengfei;MA Xiuxia;ZHANG Liujing;XU Liran(AIDS clinical Research Center,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450000,Henan,China;Henan Key Laboratory of Viral Disease Prevention and Treatment with Traditional Chinese Medicine,Zhengzhou 450000,Henan,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan Province,Zhengzhou 450046,Henan,China)

机构地区：[1]河南中医药大学第一附属医院艾滋病临床研究中心,郑州450000 [2]河南中医药大学第一临床医学院,郑州450000 [3]河南省病毒性疾病中医药防治重点实验室,郑州450000 [4]豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国艾滋病性病》2024年第6期657-662,共6页Chinese Journal of Aids & STD

基　　金：国家“十三五”科技重大专项(2017ZX10205502);河南省重点研发推广专项课题(232102311222);河南省中医药科学研究专项课题(2021JDZX2078,2023ZY2016)。

摘　　要：艾滋病cART长期应用易产生耐药性和药物不良反应。中草药和药用植物来源的天然化合物具有来源广泛、结构多样、毒性较低等特点,在艾滋病防治中具有独特优势和巨大潜力。本文对生物碱、萜类、香豆素、黄酮类等天然化合物的来源、作用机制等进行综述,以期为有效抗艾滋病药物的开发和应用提供参考。The long-term application of combined antiretroviral therapy(cART)for HIV/AIDS can lead to drug resistance and adverse drug reactions.Natural compounds derived from traditional Chinese herbs and medicinal plants have the advantages of wide sources,diverse structures,and low toxicity,showing unique strengths and significant potential in HIV/AIDS prevention and treatment.This article provides a comprehensive review of the sources and mechanisms of action of natural compounds such as alkaloids,terpenes,coumarins,and flavonoids,aiming to provide a reference for the development and application of effective anti-HIV drugs.

关 键 词：艾滋病 艾滋病病毒 天然化合物 抗艾滋病病毒活性 

分 类 号：R373.9[医药卫生—病原生物学]