超敏C反应蛋白、降钙素原与内毒素对感染性疾病的诊断意义  

Diagnostic significance of high-sensitivity C-reactive protein,procalcitonin and endotoxin in infectious diseases

作　　者：章惠萍[1] 何小帆[1] 任宁宁 ZHANG Huiping;HE Xiaofan;REN Ningning(Department of Clinical Laboratory,Hangzhou Cancer Hospital,Hangzhou 310002,China)

机构地区：[1]杭州市肿瘤医院检验科,310002

出　　处：《浙江医学》2024年第13期1401-1404,共4页Zhejiang Medical Journal

基　　金：浙江省基础公益研究计划项目(LGF19H310001)。

摘　　要：目的探讨超敏C反应蛋白(hs-CRP)、降钙素原(PCT)与内毒素(ET)对感染性疾病的诊断意义。方法回顾性选取2021年12月至2022年11月杭州市肿瘤医院收治的196例住院患者,根据感染情况分全身感染组10例、局部感染组67例和未感染组119例。比较3组患者性别、年龄、原发病和科室的差异,检测hs-CRP、PCT与ET水平,并对血液hs-CRP、PCT与ET进行相关性分析。结果3组患者原发病、科室比较差异均有统计学意义(均P<0.05),其中局部感染组恶性肿瘤患者占比高于未感染组,差异有统计学意义(P<0.05),全身感染组重症医学科患者占比高于局部感染组、未感染组,局部感染组重症医学科患者占比高于未感染组,差异均有统计学意义(均P<0.05)。与局部感染组、未感染组相比,全身感染组hs-CRP、PCT水平明显增高,差异均有统计学意义(均P<0.05)。全身感染组ET水平高于未感染组,差异有统计学意义(P<0.05)。血液hs-CRP与PCT呈正相关(P<0.01)。结论血液hs-CRP与PCT检测对住院患者全身感染的诊断具有一定意义。临床应重点关注恶性肿瘤患者和危重患者感染情况,及时、合理地调整治疗方案。Objective To explore the diagnostic significance of high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)and endotoxin(ET)in infectious diseases.Methods A total of 196 inpatients admitted to Hangzhou Cancer Hospital from December 2021 to November 2022 were retrospectively selected.According to the infection situation,they were divided into systemic infection group(n=10),local infection group(n=67)and uninfected group(n=119).The gender,age,primary disease and department information of the three groups of patients were compared,the levels of hs-CRP,PCT and ET in the three groups were detected and compared,and the correlation analysis was conducted among hs-CRP,PCT and ET.Results There were statistically significant differences in the primary disease and departments among the three groups(both P<0.05).Among which,the proportion of malignant tumor patients in the local infection group was higher than that of the uninfected group,and the difference was statistically significant(P<0.05).In the systemic infection group,the proportion of patients in the intensive care unit was higher than that of the local infection group and the uninfected group,with the proportion in the local infection group higher than that of the uninfected group(all P<0.05).Compared with local infection group and uninfected group,the levels of hs-CRP and PCT in systemic infection group were significantly increased,and the differences were statistically significant(all P<0.05).The level of ET in systemic infection group was higher than that of the noninfection group(P<0.05).The patients'blood hs-CRP was positively correlated with PCT(P<0.01).Conclusion The detection of blood hs-CRP and PCT has a certain significance in the diagnosis of systemic infection in hospitalized patients.Clinical attention should be paid to the infection of patients with malignant tumors and critically ill patients,and the treatment plan should be adjusted timely and reasonably.

关 键 词：超敏C反应蛋白 降钙素原 内毒素 感染性疾病 

分 类 号：R446.1[医药卫生—诊断学]