脑动脉粥样硬化免疫微环境研究进展  

Recent advance in immune microenvironment of cerebral atherosclerosis

作　　者：司宸铭 何艳艳 贺迎坤 梁佳 卢韬源 李晨卿 李天晓 Si Chenming;He Yanyan;He Yingkun;Liang Jia;Lu Taoyuan;Li Chenqing;Li Tianxiao(Department of Cerebrovascular Disease,People's Hospital of Zhengzhou University(He'nan Provincial People's Hospital),Zhengzhou 450003,China;He'nan International Joint Laboratory of Cerebrovascular Disease,He'nan Engineering Research Center of Cerebrovascular Intervention Innovation,Zhengzhou 450003,China;Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]郑州大学人民医院(河南省人民医院)脑血管病科,郑州450003 [2]河南省脑血管病国际联合实验室,河南省脑血管介入创新工程技术研究中心,郑州450003 [3]首都医科大学宣武医院神经外科,北京100053

出　　处：《中华神经医学杂志》2024年第5期500-506,共7页Chinese Journal of Neuromedicine

基　　金：国家卫生健康委能力建设和继续教育项目(GWJJ2023100101);河南省重点研发专项(241111313200);河南省医学科技攻关项目(232102231042);河南省医学科学技术研究计划省部级青年项目(SBGJ202303001)。

摘　　要：脑动脉粥样硬化斑块和动脉血液中存在大量巨噬细胞、中性粒细胞和自然杀伤细胞等非特异性免疫细胞及B细胞、T细胞等特异性免疫细胞。此外,干扰素-γ、白细胞介素(IL)-17和IL-1β等免疫相关调节分子在脑动脉粥样硬化病变组织中高表达,与肿瘤免疫微环境类似,影响脑动脉粥样硬化的发生发展。本文围绕脑动脉粥样硬化病变周围免疫微环境所涉及的主要免疫细胞及相关因子的研究进展进行综述,以期为临床诊疗提供思路和依据。A large number of non-specific immune cells,such as macrophages,neutrophils and natural killer cells,as well as specific immune cells,such as B cells and T cells,are presented in the atherosclerotic plaques and arterial blood.In addition,immune-related regulatory molecules such as interferon-γ,interleukin-17,and interleukin-1βhighly express in atherosclerotic lesion tissues,which is similar to the tumor immune microenvironment and influence the atherosclerosis progression.In this paper,the research progress of immune cells and related factors involved in the immune microenvironment around cerebral atherosclerotic lesions is reviewed to provide idea and basis for its clinical diagnosis and treatment.

关 键 词：脑动脉粥样硬化 免疫微环境 免疫细胞 细胞因子 

分 类 号：R543.5[医药卫生—心血管疾病]