瘦素受体基因Gln223Arg单核苷酸多态性与精液质量参数的相关性研究  

Correlation between single nucleotide polymorphism of Leptin receptor gene Gln223Arg and semen quality parameters

作　　者：刘春辉 王文第[1] 吴瑞鹏 陕文生[1] 王志强[1] 金莉娅[1] LIU Chunhui;WANG Wendi;WU Ruipeng;SHAN Wensheng;WANG Zhiqiang;JIN Liya(Department of Andrology,Gansu Provrincial Maternity and Child-care Hospital,Lanzhou 730050,Gansu,China;Department of Neurology,Gansu Provincial Hospital,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)男科,兰州730050 [2]甘肃省人民医院神经内科,兰州730000

出　　处：《中国性科学》2024年第7期5-9,共5页Chinese Journal of Human Sexuality

基　　金：甘肃省科技计划资助项目(23JRRA1743,23JRRA1754);兰州市科技发展指导性计划项目(2020-ZD-4)。

摘　　要：目的探讨瘦素受体(LEPR)基因Gln223Arg单核苷酸多态性与精液质量参数的相关性。方法选取2021年1月至12月在甘肃省妇幼保健院进行育前检查的肥胖男性156人作为观察组,另选取非肥胖男性150人作为对照组。检测LEPR基因Gln223Arg基因型,分析LEPR基因Gln223Arg多态性在两组间的分布及差异,分析基因型与精液质量各参数变化的相互关系。结果G/G型基因携带人群较A/A、A/G型携带人群发生精子密度、活力、畸形率、DFI异常的风险分别提高了1.21、2.36、1.68、1.85倍。结论LEPR基因Gln223Arg多态性可能造成男性发生肥胖的风险增加,G型等位基因较A型等位基因可能更容易造成精子质量异常的发生。Objective To investigate correlation between single nucleotide polymorphism of Leptin receptor gene Gln223Arg and semen quality parameters.Methods A total of 156 obese males who underwent pre-pregnancy examinations at Gansu Provincial Maternity and Child-care Hospital from January to December 2021 were selected as the observation group,while 150 non-obese males were selected as the control group.LEPR gene Gln223Arg genotype was detected,the distribution and differences of LEPR gene Gln223Arg polymorphism between the two groups were analyzed,and the relationship between genotype and the changes of semen quality parameters was analyzed.Results The risk of abnormal sperm density,motility,morphology,and DNA fragmentation index(DFI)in G/G genotype carriers population was 1.21,2.36,1.68,and 1.85 times higher than that in A/A and A/G genotype carriers population,respectively.Conclusions The LEPR gene Gln223Arg polymorphism may increase the risk of obesity in men,and the G-type allele may be more likely to cause abnormal sperm quality than the A-type allele.

关 键 词：瘦素受体 瘦素受体基因 单核苷酸多态性 肥胖 精液质量参数 

分 类 号：R697[医药卫生—泌尿科学]