血清PGC-1α水平与PCOS患者体外受精-胚胎移植妊娠结局的关系  

Relationship between serum peroxisome proliferator-activated receptorγcoactivator 1o level and pregnancy outcome of in vitro fertilization and embryo transfer in patients with polycystic ovarian syndrome

作　　者：兰婧[1] 蒋丽[1] 吕榜权[1] 彭晓竹 谭开亮[1] LAN Jing;JIANG Li;LYU Bangquan;PENG Xiaozhu;TAN Kailiang(Department of Gynecology,Maternal and Child Health Hospital of Guangxi,Nanning 530000,Guangxi,China)

机构地区：[1]广西壮族自治区妇幼保健院妇科,南宁530000

出　　处：《中国性科学》2024年第7期31-35,共5页Chinese Journal of Human Sexuality

基　　金：广西医疗卫生适宜技术开发与推广应用项目(S2020055)。

摘　　要：目的探析血清过氧化物酶体增殖物激活受体γ共激活因子1α(PGC-1α)水平与多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)妊娠结局的关系。方法选取2021年1月至2022年12月于广西壮族自治区妇幼保健院接受IVF-ET治疗的99例PCOS患者作为研究对象,依据患者妊娠结局分为妊娠组(n=49)和未妊娠组(n=50)。收集并比较所有患者基线资料以及性激素、血清PGC-1α水平等。采用Logistic回归分析影响PCOS患者IVF-ET妊娠结局的危险因素;采用受试者工作特征(ROC)曲线评估血清PGC-1α水平对PCOS患者IVF-ET妊娠结局的预测价值。结果99例PCOS患者中有49例妊娠成功,妊娠成功率为49.49%。未妊娠组血清甘油三酯(TG)、睾酮(T)水平均高于妊娠组,且血清PGC-1α水平低于妊娠组,差异具有统计学意义(P<0.05)。Logistic回归分析显示,血清T、TG水平高是PCOS患者IVF-ET治疗后妊娠结局的危险因素(OR>1,P<0.05),PGC-1α水平高是PCOS患者IVF-ET治疗后妊娠结局的保护因素(OR<1,P<0.05)。绘制ROC曲线显示,血清PGC-1α水平预测PCOS患者IVF-ET妊娠结局的曲线下面积(AUC)为0.752(95%CI:0.654~0.850,P<0.05),具有一定的预测价值。当血清PGC-1α的Cut-off值为0.485 ng/mL时,预测PCOS患者IVF-ET妊娠结局的灵敏度和特异度分别为76%、67%。结论血清PGC-1α水平与PCOS患者IVF-ET妊娠结局有关,且当其水平达0.485 ng/mL时,妊娠失败风险明显增加,具有一定的预测价值,未来或可将其作为预测IVF-ET妊娠结局的辅助指标。Objective To explore the relationship between serum peroxisome proliferator-activated receptorγcoactivator 1α(PGC-1α)level and pregnancy outcome of in vitro fertilization and embryo transfer(IVF-ET)in patients with polycystic ovarian syndrome(PCOS).Methods From January 2021 to December 2022,99 PCOS patients who received IVF-ET treatment in Maternity and Child Health Care of Guangxi were selected as the study subjects.According to the pregnancy outcomes,the patients were divided into pregnancy group(n=49)and non-pregnancy group(n=50).The baseline data of all patients,as well as the levels of sex hormones and serum PGC-1αwere collected and compared.Logistic regression analysis was used to analyze the risk factors for IVF-ET pregnancy outcomes in PCOS patients.And the predictive value of serum PGC-1αlevel on IVF-ET pregnancy outcomes in PCOS patients was evaluated using the receiver operating characteristic(ROC)curve.Results Among the 99 patients with PCOS,49 cases had successful pregnancies,with a success rate of 49.49%.The serum triglyceride(TG)and testosterone(T)levels in the non-pregnancy group were all higher than those in the pregnancy group,and the serum PGC-1αlevel was lower than those in the pregnancy group,with statistical significant differences(P<0.05).Logistic regression analysis showed that high serum T and TG levels were risk factors for pregnancy outcome after IVF-ET treatment(OR>1,P<0.05),and high PGC-1αlevel was a protective factor for pregnancy outcome after IVF-ET treatment in PCOS patients(OR<1,P<0.05).ROC curve was drawn and displayed the area under curve(AUC)of serum PGC-1αlevel predicting IVF-ET pregnancy outcome in PCOS patients was 0.752(95%CI:0.654-0.850,P<0.05),which had certain predictive value.When the Cut-off value of serum PGC-1αreached 0.485 ng/mL,the sensitivity and specificity of predicting IVF-ET pregnancy outcome in PCOS patients were 76%and 67%,respectively.Conclusions Serum PGC-1αlevel is related to IVF-ET pregnancy outcome in PCOS patients,and when its level reaches

关 键 词：多囊卵巢综合征 体外受精-胚胎移植 妊娠结局 过氧化物酶体增殖物激活受体γ共激活因子1α 

分 类 号：R711[医药卫生—妇产科学]