生殖器念珠菌病患者致病菌分布情况和血清氧化应激因子表达水平及临床意义  

The distribution of pathogenic bacteria and the expression levels and clinical significance of serum oxidative stress factors in patients with genital candidiasis

作　　者：朱峰 徐永 何晓雨 ZHU Feng;XU Yong;HE Xiaoyu(Department of Dermatology,Fuyang Wormen and Children's Hospital,Fuyang 236000,Anhui,China;Department of STD and AIDS Prevention and Treatment,Fuyang Disease Prevention and Control Center,Fruyang 236000,Anhui,China;Department of Dermatology,Affiliated Hospital of Jiangsu University,Zhenjiang 210031,Jiangsu,China)

机构地区：[1]阜阳市妇女儿童医院皮肤科,安徽阜阳236000 [2]阜阳市疾病预防控制中心性病艾滋病防治科,安徽阜阳236000 [3]江苏大学附属医院皮肤科,江苏镇江210031

出　　处：《中国性科学》2024年第7期141-145,共5页Chinese Journal of Human Sexuality

基　　金：2020年度安徽省自然科学基金项目(2008085QH430)。

摘　　要：目的探究生殖器念珠菌病患者致病菌分布情况,以及血清氧化应激因子表达水平及临床意义。方法选取2020年5月至2023年8月阜阳市妇女儿童医院收治120例生殖器念珠菌病患者作为研究对象,设为研究组,分析致病菌分布情况。另选取同期进行体检的86例健康者作为对照组。比较两组血清氧化应激因子水平,分析血清氧化应激因子水平对生殖器念珠菌病的诊断价值。研究组根据病情严重程度分为轻度组(n=63)、中度组(n=38)与重度组(n=19),比较三组的血清氧化应激因子水平,分析血清氧化应激因子水平与病情严重程度的相关性。结果120例生殖器念珠菌病患者分离致病菌主要为白色念珠菌(79例,65.83%),光滑念珠菌、热带念珠菌、克柔念珠菌及近平滑念珠菌分别占15.00%(18例)、12.50%(15例)、6.67%(8例)。研究组总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物歧化酶(GSH-PX)和过氧化氢酶(CAT)等氧化应激因子水平均显著低于对照组(P<0.05);受试者工作特征(ROC)曲线结果显示,T-AOC、SOD、GSH-PX与CAT诊断生殖器念珠菌病的曲线下面积(AUC)分别为0.785、0.778、0.819、0.609。重度组T-AOC、SOD、GSH-PX与CAT等氧化应激因子水平低于中度组、轻度组,且中度组低于轻度组(P<0.05);Spearman相关性分析结果显示,T-AOC、SOD、GSH-PX与CAT等氧化应激因子水平与患者病情严重程度呈负相关(r=-0.534、-0.612、-0.438、-0.396,P<0.05)。结论生殖器念珠菌病患者的致病菌主要为白色念珠菌,患者体内氧化应激反应增强,氧化应激因子可用于患者病情诊断及病情严重程度评估。Objective To investigate the distribution of pathogenic bacteria and the expression levels and clinical significance of serum oxidative stress factors in patients with genital candidiasis.Methods A total of 120 patients with genital candidiasis treated in Fuyang Women and Children′s Hospital from May 2020 to August 2023 were selected as the research objects and was regarded as the study group.The distribution of the pathogenic bacteria was analyzed.Another 86 healthy subjects underwent physical examination during the same period were selected as the control group.The serum levels of oxidative stress factors were compared in both groups.The diagnostic value of serum oxidative stress factors levels in genital candidiasis was analyzed.The study group was divided into mild group(n=63),moderate group(n=38)and severe group(n=19)according to the severity of the disease.The levels of serum oxidative stress factors levels in the three groups were compared,and the correlation of serum oxidative stress factors levels and the severity of the disease was analyzed.Results The main pathogenic bacteria isolated from the 120 patients were mainly Candida albicans(79 cases,65.83%).The proportions of Candida glabrata,Candida tropicalis,Candida Klurensis and Candida parapsilosis were 15.00%(18 cases),12.50%(15 cases)and 6.67%(8 cases),respectively.The levels of oxidative stress factors including total antioxidant capacity(T-AOC),superoxide dismutase(SOD),glutathione peroxidase dismutase(GSH-PX)and catalase(CAT)in the study group were all significantly lower than those in the control group(P<0.05).The receiver operating characteristic(ROC)curve shows that the area under the curve(AUC)of T-AOC,SOD,GSH-PX and CAT for diagnosis of genital candidiasis was 0.785,0.778,0.819 and 0.609,respectively.The levels of oxidative stress factors such as T-AOC,SOD,GSH-PX and CAT in the severe group were lower than those in the moderate group and the mild group,and those in the moderate group were lower than those in the mild group(P<0.05).Spearman c

关 键 词：生殖器念珠菌病 致病菌分布 氧化应激因子 临床意义 

分 类 号：R759[医药卫生—皮肤病学与性病学]