纳米孔测序技术在感染性疾病病原微生物鉴定中的研究进展  

Application of nanopore sequencing in identification of pathogens for infectious disease

作　　者：贾继民(综述)[1] 段蕾 董路宁 杜子玥(审校) JIA Jimin;DUAN Lei;DONG Luning;DU Ziyue(Center for Disease Control and Prevention of Xinjiang Military Command,Urumqi,Xinjiang,830011,China)

机构地区：[1]新疆军区保障部疾病预防控制中心,新疆乌鲁木齐830011

出　　处：《检验医学与临床》2024年第S01期136-139,共4页Laboratory Medicine and Clinic

基　　金：军队生物安全研究专项基金支持项目(20SWAQK49)。

摘　　要：感染性疾病是严重威胁人类健康的重大疾病之一。当前,全球感染性疾病的发病率有所上升,而病原微生物呈现多样化、复杂化。随着近年来快速发展的全基因组测序技术,可直接对病原微生物进行鉴定,比传统的病原微生物的鉴定有微生物鉴定中具有独特的优势。因此,本文概述了纳米孔测序技术在病毒、细菌病原鉴定、抗药性基因分析以及宏基因组中的应用。Infectious disease is one of the major diseases that seriously impacted human health.Currently,the incidence of infectious diseases has increased globally,and pathogens are diverse and complex.Pathogens can be identified directly with the rapid development of whole genome sequencing technology in recent years,which has advantages in comparison with traditional methods for pathogen identification.Thus,this paper provides an overview of the application for Nanopore sequencing technology in viral and bacterial pathogen identification,antimicrobial resistance gene analysis and application in metagenomics.

关 键 词：纳米孔测序 病原微生物鉴定 宏基因组测序 

分 类 号：R446.5[医药卫生—诊断学]