沙库巴曲缬沙坦钠片治疗慢性心力衰竭的疗效及对血清CysC、 BNP水平的影响  

Effect of sacubitril valsartan sodium tablets in treating chronic heart failure and its influence on serum CysC and BNP levels

作　　者：苏虹 李仕林 严定一 陈霞 SU Hong;LI Shilin;YAN Dingyi;CHEN Xia(Department of Cardiology,Xi′an Municipal Third Hospital,Xi′an,Shaanxi 710018,China;Department of Neurology,Xi′an Municipal Third Hospital,Xi′an,Shaanxi 710018,China)

机构地区：[1]西安市第三医院心血管内科,陕西西安710018 [2]西安市第三医院神经内科,陕西西安710018

出　　处：《检验医学与临床》2024年第14期2066-2070,共5页Laboratory Medicine and Clinic

基　　金：陕西省西安市科技计划项目(21YXYJ0041);陕西省西安市卫生健康委员会科研项目(2023yb09)。

摘　　要：目的探讨沙库巴曲缬沙坦钠片治疗慢性心力衰竭(CHF)的疗效及对血清胱抑素C(CysC)、脑钠肽(BNP)水平的影响。方法选取该院2021年1月至2023年1月收治的88例CHF患者为研究对象,采用随机数字表法将其分为观察组和对照组,每组44例。观察组在常规治疗的基础上口服沙库巴曲缬沙坦钠片,对照组在常规治疗的基础上口服缬沙坦片。观察2组疗效,检测2组治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)及血清CysC、BNP水平,记录2组治疗前后的明尼苏达心力衰竭生活质量量表(MLHFQ)评分和6 min步行试验(6MWT)结果,统计2组不良反应情况和再入院情况。结果观察组疗效优于对照组(P<0.05);与治疗前比较,治疗后2组LVEF上升,LVEDD、LVESD下降,且观察组LVEF高于对照组,LVEDD、LVESD低于对照组,差异均有统计学意义(P<0.05);2组治疗后CysC、BNP水平较治疗前明显下降,且观察组CysC、BNP水平低于对照组,差异均有统计学意义(P<0.05);治疗后2组6MWT距离较治疗前变长,MLHFQ评分降低,且观察组6MWT距离长于对照组,MLHFQ评分低于对照组,差异均有统计学意义(P<0.05);2组不良反应总发生率分别为15.91%和20.45%,差异无统计学意义(P=0.498)。观察组再入院率为4.55%,明显低于对照组的18.18%(P<0.05)。结论沙库巴曲缬沙坦钠片治疗CHF疗效较好,能有效改善患者心功能,降低血清CysC、BNP水平和再入院率,提高患者运动耐量和生活质量,同时无严重不良反应发生,安全性高。Objective To investigate the effects of sacubitril valsartan sodium tablets in the treatment of chronic heart failure(CHF)and its influence on serum cystatin C(CysC)and brain natriuretic peptide(BNP)levels.Methods Eighty-eight cases of CHF admitted and treated in this hospital from January 2021 to January 2023 were selected as the study subjects and divided into the observation group and control group by the random number table method,44 cases in each group.The observation group orally took sacubitril valsartan sodium tablets on the basis of routine treatment,while the control group orally took valsartan tablets on the basis of routine treatment.The treatment effects were observed in the two groups.The left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left ventricular ejection fraction(LVEF),serum CysC and BNP levels before and after treatment in the two groups were detected,the Minnesota Heart Failure Quality of Life Scale(MLHFQ)scores and 6-min walking test(6MWT)results before and after treatment in both groups were recorded,and the adverse reactions and readmission status were statistically analyzed in both groups.Results The effect of the observation group was better than that of the control group(P<0.05).Compared with before treatment,LVEF after treatment in the two groups was increased,while LVEDD and LVESD were decreased,moreover LVEF in the observation group was higher than that in the control group,while LVEDD and LVESD were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of CysC and BNP after treatment in the two groups significantly decreased compared with before treatment,moreover the levels of CysC and BNP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,6MWT distance in the two groups was significantly longer than that before treatment,the MLHFQ score was decreased,moreover 6MWT distance in the observation

关 键 词：慢性心力衰竭 沙库巴曲缬沙坦钠片 缬沙坦片 胱抑素C 脑钠肽 

分 类 号：R541.4[医药卫生—心血管疾病] R446.1[医药卫生—内科学]