类风湿关节炎对骨破坏相关影响因素的研究进展  

Research Progress on Influencing Factors of Bone Destruction in Rheumatoid Arthritis

作　　者：王香琳 张杰[2] WANG Xianglin;ZHANG Jie(Liaoning University of Traditional Chinese Medicine,Shenyang 110874,Liaoning,China;The First Affiliated Hospital of China Medical University,Shenyang 110001,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]中国医科大学附属第一医院,辽宁沈阳110001

出　　处：《实用中医内科杂志》2024年第7期10-12,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(81973661)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是一类常见的自身免疫性疾病,其特点主要是发病缓慢,全身多关节呈对称性疼痛与肿胀,病情如不能得到及时控制,后期会引起骨质破坏,严重者会导致关节畸形与残疾,大大降低了患者生活质量。通常患者在发病2年以上就容易引起骨质损伤,骨损伤往往是难以修复的。目前类风湿关节炎仍未有完全根治的方法,只有不到一半患者病情得到了缓解,这与骨破坏在其发病机制的尚未完全阐明息息相关。Rheumatoid arthritis(RA)is a kind of common autoimmune disease,which is characterized by slow onset,symmetrical pain and swelling in multiple joints of the whole body.If the progress of the disease is not controlled in time,it will cause bone destruction in the later stage,and even lead to joint deformity and disability in severe cases,which greatly reduces the quality of life of patients.Usually,patients are prone to bone damage after more than two years of onset,and bone damage is often difficult to repair.Up to now,there is still no complete cure for rheumatoid arthritis,and less than half of patients with RA have been relieved,which is closely related to the fact that the pathogenesis of bone destruction has not been fully clarified.

关 键 词：类风湿关节炎 骨破坏 破骨细胞 成骨细胞 

分 类 号：R274[医药卫生—中医骨伤科学]