脑胶质细胞凋亡相关信号通路对缺血性脑卒中影响的现代研究进展  

Modern Research Progress on the Effect of Glial Cell Apoptosis-Related Signaling Pathways on Ischemic Stroke

作　　者：秦娜 刘馨越 郑淇元 张帅[1] 陈天傲 曲怡 王建波 吴际 QIN Na;LIU Xinyue;ZHENG Qiyuan;ZHANG Shuai;CHEN Tianao;QU Yi;WANG Jianbo;WU Ji(The First Clinical College of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Key Laboratory of Traditional Chinese Medicine Viscera Theory and Application,Ministry of Education,Shenyang 110847,Liaoning,China;Shenyang Medical College,Shenyang 110034,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]中医脏象理论及应用教育部重点实验室,辽宁沈阳110847 [3]沈阳医学院,辽宁沈阳110034

出　　处：《实用中医内科杂志》2024年第7期120-124,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：辽宁省教育厅项目(LJKMZ20221315,L202025);辽宁中医药大学大学生创新创业国家级项目(202210162012)。

摘　　要：缺血性脑卒中(ischemic stroke,IS)又称脑梗死,是指由于脑的供血动脉(颈动脉和椎动脉)狭窄或闭塞、脑供血不足导致的脑组织缺血性坏死,而出现相应的神经功能缺损的脑血管疾病。IS后脑神经元损伤的病理、生理机制是研究最为活跃的领域之一,其机制十分复杂,可分为凋亡和坏死两种。其中凋亡过程主要是因为存在大量正性以及负性的可调控信号,因此凋亡可以作为脑缺血治疗的潜在靶点。未来要面对IS的预防、治疗以及康复等多方面的问题。文章讨论研究外源性凋亡途径、内源性凋亡途径以及途径中Bcl-2、Caspase家族以及NF-κB等凋亡基因的相关作用机制与IS的关系。Ischemic stroke(IS),also known as cerebral infarction,refers to a cerebrovascular disease in which the cerebral supply arteries(carotid artery and vertebral artery)are narrowed or occluded,and the cerebral blood supply is insufficient,resulting in avascular necrosis of brain tissue,and resulting in corresponding neurological deficits.The pathological and physiological mechanism of neuronal injury after IS is one of the most active academic fields,its mechanism is very complex,and can be divided into two types:apoptosis and necrosis.There are a large number of positive and negative regulated signals in apoptosis,so they can be used as potential targets for the treatment of cerebral ischemia.In the future,we will have to face many problems such as prevention,treatment of IS,and post-illness rehabilitation.The objective of this review is to investigate the mechanisms of exogenous apoptotic pathways,endogenous apoptotic pathways,research apoptotic genes,such as Bcl-2,Caspase family,and NF-κB,and elaborate their relationship with IS.

关 键 词：缺血性脑卒中 凋亡 BCL-2家族 作用机制 脑胶质细胞 

分 类 号：R255.2[医药卫生—中医内科学]