接骨七厘片联合椎体后凸成形术治疗骨质疏松爆裂性骨折疗效观察  

Clinical observation on Jiegu Qili Pills combined with kyphoplasty in treatment of osteoporotic burst fracture

作　　者：赵犹太 边文超 张伟 王轶 吕东升 ZHAO You-tai;BIAN Wen-chao;ZHANG Wei;WANG Yi;LYU Dong-sheng(Huairou Hospital of Beijing Hospital of Traditional Chinese Medicine,Beijing 101400)

机构地区：[1]北京中医医院怀柔医院,北京101400

出　　处：《湖北中医药大学学报》2024年第3期82-85,共4页Journal of Hubei University of Chinese Medicine

基　　金：北京市属医院科研培育计划项目(项目编号:PZ2021018)。

摘　　要：目的观察接骨七厘片联合椎体后凸成形术(PKP)治疗骨质疏松爆裂性骨折(OPBF)疗效。方法将我院71例OPBF患者随机分为治疗组36例与对照组35例。对照组采用PKP治疗,治疗组采用接骨七厘片联合PKP治疗。对比两组临床疗效、Lane-Sandhu X线评分;两组骨密度(BMD)值、I型原胶原N-端前肽(P1NP)、碱性磷酸酶(ALP)含量;两组中医主症和次症证候、视觉模拟评分法(VAS)、Oswestry功能障碍指数(ODI)评分;两组伤椎前缘和中央高度、后凸Cobb角、椎管占位率。对比愈合时间。结果术后12个月,治疗组总有效率高于对照组(P<0.05);术后3个月、6个月、12个月治疗组Lane-Sandhu X线评分、BMD高于对照组(P<0.05);术后3个月两组P1NP、ALP含量低于术前,治疗组P1NP、ALP含量低于对照组(P<0.05);术后3个月两组主症和次症证候评分低于术前,治疗组主症和次症证候评分低于对照组(P<0.05);术后3个月两组VAS、ODI、伤椎前缘和中央高度、后凸Cobb角、椎管占位率低于术前,治疗组VAS、ODI、伤椎后凸Cobb角低于对照组(P<0.05);两组伤椎前缘高度、伤椎中央高度、椎管占位率差异无统计学意义(P>0.05);治疗组愈合时间短于对照组(P<0.05)。结论接骨七厘片联合PKP是治疗OPBF有效的方法,能显著缩短骨折愈合时间,改善疼痛和功能障碍,增加BMD含量,降低骨代谢水平,且对伤椎稳定性无影响。Objective To observe the efficacy of Jiegu Qili Pills combined with kyphoplasty(PKP)in treatment of osteoporotic burst fracture(OPBF).Methods 71 cases of OPBF patients were randomly divided into treatment group(36cases)and control group(35 cases).Control group was treated with PKP,while treatment group was treated with Jiegu Qili Pills on the basis of control group.The clinical efficacy and Lane-Sandhu X-ray scores,bone mineral density(BMD)value,N-terminal propeptide(P1NP)and alkaline phosphatase(ALP)content of type I procollagen,the main and secondary syndromes,Visual Analogue Scale(VAS)and Oswestry Dysfunction Index(ODI)scores,the anterior and central heights of the injured vertebrae,kyphotic Cobb angle,spinal canal mass,and healing time in the two groups were compared.Results The total apparent efficiency of treatment group in 12 months after surgery was higher than that in control group(P<0.05);the LaneSandhu X-ray score and BMD in treatment group at 3 months,6 months and 12 months after surgery were higher than those in control group(P<0.05);the P1NP and ALP contents in both groups were lower than those before operation in 3 months after operation,and were lower in treatment group than control group(P<0.05);the VAS,ODI scores,anterior and central height of the injured vertebrae,kyphotic Cobb angle and spinal canal occupancy rate were lower in both groups at 3 months after operation than before operation,and were lower in treatment group than control group(P<0.05);there was no significant difference in the height of the anterior edge of the injured vertebrae,the height of the central vertebra,and the mass of the spinal canal between the two groups(P>0.05),and the healing time in treatment group was shorter than that in control group(P<0.05).Conclusion Jiegu Qili Pills combined with PKP is an effective method for the treatment of OPBF,which significantly shortens the fracture healing time,improves pain and functional impairment,increases BMD,decreases TCM syndrome scores,and decreases bone metabolism level,and

关 键 词：骨质疏松 爆裂性骨折 椎体后凸成形术 接骨七厘片 

分 类 号：R274.1[医药卫生—中医骨伤科学]