基于中西医临床病证特点的肝硬化腹水动物模型分析  

Analysis of Animal Models of Hepatic Ascites Based on Clinical Evidence Characteristics of Traditional Chinese and Western Medicine

作　　者：郇宇 秦世磊 姬叔梅 南硕 胡毅龙 左艇[1] 苗明三[1,2] HUAN Yu;QIN Shilei;JI Shumei;NAN Shuo;HU Yilong;ZUO Ting;MIAO Mingsan(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046 [2]豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国实验方剂学杂志》2024年第15期200-205,共6页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82274119);河南省重大科技专项(221100310400);河南省重大公益专项(201300310100);岐黄学者项目(国中医药人教函2022-6)。

摘　　要：肝硬化腹水是肝硬化失代偿期常见且疑难的并发症之一,其发病率日益增高。临床肝硬化腹水患者手术治疗预后较差且病情易反复。中医治疗肝硬化腹水有一定优势,然而符合中医证型的肝硬化腹水动物模型的制备尚无统一标准。因此,该文对肝硬化腹水的动物模型相关文献进行总结,同时基于肝硬化腹水的中西医临床诊断标准,对现有的肝硬化腹水动物模型进行分析。结果发现肝硬化腹水常用的造模方法单因素法、复合因素诱导法、手术法、免疫法等造模方法,多由西医理论指导,其发病机制多与西医致病机制相符,与中医证型尚存在一定差异,因此建议模型制备过程中施加中医干预因素,进一步制备符合中西医临床病证特点的肝硬化腹水动物模型。Hepatic ascites is one of the common and difficult complications in the decompensated stage of liver cirrhosis,and its incidence is increasing.In clinical practice,the prognosis of patients with hepatic ascites after surgery is worse,and the disease is recurrent.Traditional Chinese medicine(TCM)has certain advantages in treating hepatic ascites.However,there is no uniform standard for the preparation of animal models of hepatic ascites in accordance with TCM evidence.Therefore,this paper summarized the literature on animal models of hepatic ascites and analyzed the existing animal models of hepatic ascites based on the clinical diagnostic criteria of hepatic ascites in TCM and western medicine.The results show that the commonly used modeling methods for hepatic ascites mainly include the single-factor method,composite factor induction method,surgical method,and immunization method.Most of them are guided by western medicine theories,and their pathogenic mechanisms are mostly consistent with those of western medicine and are different from TCM evidence.Therefore,it is suggested that TCM intervening factors should be imposed in the process of model preparation,so as to prepare an animal model of hepatic ascites that meets the clinical evidence characteristics of TCM and western medicine.

关 键 词：肝硬化腹水 诊断标准 吻合度 模型分析 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33