葛根芩连汤及其加减方改善2型糖尿病胰岛素抵抗作用研究进展  

Gegen Qinliantang and Its Modified Prescriptions Ameliorate Insulin Resistance in Type 2 Diabetes Mellitus:A Review

作　　者：刘艺敏 吉燕华 陈梦婕 严小军[1] 刘红宁[1] 曾治君[1] LIU Yimin;JI Yanhua;CHEN Mengjie;YAN Xiaojun;LIU Hongning;ZENG Zhijun(Research Center for Differentiation and Development of Traditional Chinese Medicine(TCM)Basic Theory,Jiangxi Province Key Laboratory of TCM Etiopathogenisis,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学中医基础理论分化发展研究中心,江西省中医病因生物学重点实验室,南昌330004

出　　处：《中国实验方剂学杂志》2024年第15期256-263,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81760787);江西省中医药中青年骨干人才项目(赣中医药科教字[2021]2号);江西中医药大学校级科技创新团队发展计划项目(CXTD22007)。

摘　　要：葛根芩连汤出自《伤寒杂病论》,为表里双解治疗协热下利的代表方剂,全方由葛根、黄芩、黄连、炙甘草配伍而成,四药合用可外疏内清,共达清热止利,表里同解之效。现临床上基于异病同治的原则将葛根芩连汤用于2型糖尿病(T2DM)的治疗,取得了良好的疗效。T2DM是一种以血糖水平升高为主要特征的慢性代谢性疾病,其病因和发病机制十分复杂,主要与遗传、生活方式、环境及饮食等因素相关。临床观察及实验研究显示,葛根芩连汤及其药效成分可有效防治T2DM。临床上常将葛根芩连汤加减应用或联合西药应用,其治疗效果明显优于单独使用西药。临床实践证实葛根芩连汤可以有效缓解T2DM患者临床症状,减轻胃肠道等不良反应,并减少并发症的发生。实验研究表明葛根芩连汤可通过调控胰岛传导通路及炎症信号通路、缓解氧化应激反应、调节肠道菌群等方式来增强患者胰岛功能,改善胰岛素抵抗,从而治疗T2DM。但目前关于葛根芩连汤通过改善胰岛素抵抗治疗T2DM的机制尚待进一步研究,故该文就葛根芩连汤改善T2DM胰岛素抵抗的临床及实验基础研究进展进行系统综述,以期为葛根芩连汤治疗T2DM作用机制的后续深入研究及其临床防治提供理论和数据参考。Gegen Qinliantang is a representative prescription for dual releasing of exterior and interior and treating diarrhea with fever in the Treatise on Cold Damage and Miscellaneous Diseases(《伤寒杂病论》).This prescription consists of Puerariae Lobatae Radix,Scutellariae Radix,Coptidis Rhizoma,and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle.The combination of the four herbal medicines has the ability to clear both the exterior and the interior,thereby halting diarrhea and clearing heat.According to the idea of treating different diseases with the same method,Gegen Qinliantang is used in clinical practice to treat type 2 diabetes mellitus(T2DM),which demonstrates positive outcomes.T2DM is a chronic metabolic disease characterized by elevated blood glucose levels.The etiology and pathogenesis of T2DM are complex,mainly related to heredity,lifestyle,environment,diet and other factors.Clinical observations and experimental studies have shown that Gegen Qinliantang and its effective ingredients have significant effects of preventing and treating T2DM.Clinically,Gegen Qinliantang is often applied with modification,or in combination with Western drugs,demonstrating better therapeutic effects than Western drugs alone.Clinical practice has confirmed that Gegen Qinliantang can effectively alleviate the clinical symptoms,reduce the occurrence of complications,and alleviate gastrointestinal adverse reactions in T2DM patients.Experimental studies have demonstrated that Gegen Qinliantang can ameliorate insulin resistance and boost pancreatic function by regulating the insulin and inflammation signaling pathways,alleviating oxidative stress,and modulating gut microbiota to treat T2DM.Nevertheless,more thorough studies remain to be carried out to decipher the mechanism of Gegen Qinliantang in ameliorating insulin resistance in T2DM.To provide theoretical and data references for the subsequent in-depth research on the mechanism of Gegen Qinliantang in treating T2DM and the prevention and treatment of this disease,this

关 键 词：葛根芩连汤 2型糖尿病 胰岛素抵抗 临床应用 作用机制 

分 类 号：R2-0[医药卫生—中医学] R33[文化科学—情报学] G353.11R587.1