中医药干预PI3K/Akt信号通路治疗前列腺癌研究进展  

Treatment of Prostate Cancer by Targeting PI3K/Akt Signaling Pathway with Traditional Chinese Medicine:A Review

作　　者：李生龙 田大成 高杰 卢刚刚 李慧 赵渊博 龚美胜 赵永强[3] 贾云鹏[3] 梁永林 LI Shenglong;TIAN Dacheng;GAO Jie;LU Ganggang;LI Hui;ZHAO Yuanbo;GONG Meisheng;ZHAO Yongqiang;JIA Yunpeng;LIANG Yonglin(School of Traditional Chinese and Western Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China;Graduate School,Heilongjiang Academy of Chinese Medicine,Harbin 150006,China;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;School of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中西医结合学院,兰州730000 [2]黑龙江省中医药科学院研究生院,哈尔滨150006 [3]甘肃省中医院,兰州730050 [4]甘肃中医药大学基础医学院,兰州730000

出　　处：《中国实验方剂学杂志》2024年第15期290-298,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：甘肃省自然科学基金项目(22JR5RA638);甘肃省科学技术厅重点研发项目(22YF7FA101);国家社会科学基金项目(18XMZ031)。

摘　　要：前列腺癌(PCa)是男性泌尿生殖系统中最常见的恶性肿瘤之一。磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路是一种致癌途径,在多种癌症中负责迁移、增殖和耐药。近年来,随着对PCa发病机制的不断研究,PI3K/Akt信号通路在PCa发展中的关键作用已备受关注。中医药以其多成分、多靶点、多途径的综合调节作用,在治疗PCa方面展现出巨大潜力。该文通过综述中医药干预PI3K/Akt信号通路在治疗PCa中的研究进展,探讨了PI3K/Akt信号通路在PCa中的表达,包括抑制PCa细胞凋亡、促进PC细胞周期运行和侵袭转移、促进肿瘤组织血管形成及介导雄激素受体(AR)等。同时,总结了干预调控该通路的单味中药主要包括白花蛇舌草、南方红豆杉、牛黄、白术等;中药活性成分主要有黄酮类、生物碱类、萜类、多酚类、木脂素类及其他类化合物;中药复方主要包括温肾散结方、健脾利湿化瘀方、益肾通癃汤、芪蓝方、西黄丸及加味参芪地黄汤等。以期为深入理解PCa的发病机制和寻找潜在的治疗靶点提供重要科学依据,并为PCa的临床研究和药物研制提供新的思路。Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system.The phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway is a carcinogenic pathway responsible for the migration,proliferation,and drug resistance of various cancers.In recent years,as the research on the pathogenesis of PCa is deepening,the role of the PI3K/Akt signaling pathway in the development of PCa has attracted much attention.Traditional Chinese medicine,comprehensively regulating multiple components,targets,and pathways,has shown great potential in the treatment of PCa.This article reviews the research progress of traditional Chinese medicine targeting the PI3K/Akt signaling pathway in the treatment of PCa and discusses the expression of the PI3K/Akt signaling pathway in PCa,which involves inhibiting apoptosis of PCa cells,promoting the cell cycle,invasion,and migration of PCa cells,promoting tumor tissue angiogenesis,and mediating the androgen receptor.Additionally,it summarizes the single Chinese medicines that target and regulate this pathway,including Hedyotis diffusa,Taxus chinensis,Bovisc Alculus,and Atractylodis Macrocephalae Rhizoma.The active ingredients of these Chinese medicines mainly include flavonoids,alkaloids,terpenes,polyphenols,lignans,and other compounds.The Chinese medicine compound prescriptions targeting the PI3K/Akt pathway mainly include Wenshen Sanjie prescription,Jianspi Lishi Huayu prescription,Yishen Tonglongtang,Qilan prescription,Xihuangwan,and modified Shenqi Dihuangtang.This review is expected to provide a scientific basis for deeply understanding the pathogenesis of PCa and identifying potential therapeutic targets,as well as to provide new ideas for clinical research and drug development for PCa.

关 键 词：前列腺癌 磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt) 信号通路 中医药 研究进展 

分 类 号：R242[医药卫生—中医临床基础] R2-0[医药卫生—中医学] R2-031R699R737.25