填精益髓汤加减治疗脑梗死后痴呆的疗效观察  

Efficacy of Modified Tianjing Yisui Decoction(填精益髓汤加减)in Treatment of Dementia after Cerebral Infarction

作　　者：刘亚鸽 李坤彬 姚先丽[1] 吴志远[1] 温小鹏[1] 李小杏[1] LIU Yage;LI Kunbin;YAO Xianli;WU Zhiyuan;WEN Xiaopeng;LI Xiaoxing(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450000,Henan,China)

机构地区：[1]郑州大学附属郑州市中心医院神经康复科,河南郑州450000

出　　处：《辽宁中医杂志》2024年第7期100-103,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：河南省医学科技攻关计划项目(2018020808)。

摘　　要：目的 探讨填精益髓汤加减治疗脑梗死后痴呆的疗效。方法 选取2020年4月—2022年6月于该院进行治疗的128例脑梗死后痴呆患者,依据随机数字表法分为对照组与观察组,各64例。两组均予以常规西医治疗,对照组采取填精益髓汤加减治疗,两组均治疗8周。分析两组治疗疗效;比较两组治疗前后中医证候得分、认知功能[简易智力状态检查量表(MMSE)、长谷川痴呆量表(HDT)、画钟试验(CDT)]及炎症因子[白细胞介素-8(IL-8)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)]。结果 治疗前,两组中医证候得分、MMSE、HDS、CDT、IL-8、TNF-α、IL-6差异比较不具有统计学意义(P>0.05)。治疗后,观察组临床疗效、MMSE、HDS、CDT得分高于对照组,中医证候得分及IL-8、TNF-α、IL-6水平低于对照组,差异具有统计学意义(P<0.05)。结论 脑梗死痴呆后患者采取填精益髓汤加减治疗临床疗效较好,可明显改善患者临床症状,促进认知功能恢复,降低炎症反应,可推广应用。Objective To investigate the efficacy of Modified Tianjing Yisui Decoction(填精益髓汤加减)in the treatment of dementia after cerebral infarction.Methods A total of 128 patients with dementia after cerebral infarction were treated in the hospital from April 2020 to June 2022.They were assigned to a control group and an observation group by random number table method with 64 cases in each group.Both groups were treated with conventional western medicine,and the patients in the observation group were additionally treated with Modified Tianjing Yisui Decoction.Both groups were given 8 weeks of treatment.Therapeutic effects,TCM symptom scores,cognitive function[Minimum Mental State Examination(MMSE),Hasegawa Dementia Scale(HDS)and Clock Draw Test(CDT)]and inflammatory factors[interleukin-8(IL-8),tumor necrosis factor(TNF-α)and interleukin-6(IL-6)]were compared between the groups.Results There were no significant differences in TCM symptom scores,MMSE score,HDS score,CDT score,the levels of IL-8,TNF-αor IL-6 between the groups before treatment(P>0.05).After treatment,the clinical response rate,MMSE score,HDS score and CDT score of the observation group were higher than those of the control group.The TCM symptom scores and the levels of IL-8,TNF-αand IL-6 were lower than those in the control group(P<0.05).Conclusion Modified Tianjing Yisui Decoction is effective in the treatment of dementia after cerebral infarction,which can significantly improve the clinical symptoms,promote the recovery of cognitive function and reduce inflammatory response.

关 键 词：填精益髓汤 脑梗死 中医治疗 临床疗效 认知功能 

分 类 号：R255.2[医药卫生—中医内科学]