桃红四物汤联合西药治疗心力衰竭合并心绞痛的效果及对ET-1、NT-proBNP及心衰标志物的影响  

Effect of Taohong Siwu Decoction(桃红四物汤)Combined with Western Medicine in Treatment of Heart Failure Complicated with Angina Pectoris and Its Influence on ET-1,NT-proBNP and Markers of Heart Failure

作　　者：卞华兴 庄燕[1] 高永兴[1] BIAN Huaxing;ZHUANG Yan;GAO Yongxin(Department of Cardiology,Jiangyin Hospital of Traditional Chinese Medicine,Jiangyin 214400,Jiangsu,China)

机构地区：[1]江阴市中医院,江苏江阴214400

出　　处：《辽宁中医杂志》2024年第7期119-122,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的 探讨桃红四物汤联合西药治疗心力衰竭合并心绞痛的效果及对内皮素-1(ET-1)、N末端B型利钠肽原(NT-proBNP)及心衰标志物的影响。方法 选择2020年1月—2022年1月在医院接受治疗的77例心力衰竭合并心绞痛患者,采用随机数表法分为试验组39例和对照组38例。对照组给瑞舒伐他汀钙治疗,试验组给予桃红四物汤联合瑞舒伐他汀钙治疗。比较两组临床疗效、ET-1、NT-proBNP、B型利钠肽(BNP)、超敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)、发作频率、持续时间及并发症发生情况。结果 治疗后,两组总有效率比较差异显著(P<0.05);治疗后,两组血清ET-1、NT-proBNP水平均降低,试验组降低更为明显,(P<0.05);治疗后,两组血清BNP、IL-6及hs-CRP水平均降低,试验组降低更为明显,(P<0.05);治疗后,两组发作频率、持续时间均降低,试验组降低更为明显,(P<0.05);两组并发症主要为恶心呕吐、头晕及腹泻,比较无显著差异(P>0.05)。结论 在心力衰竭合并心绞痛中桃红四物汤联合瑞舒伐他汀钙具有较好的效果,可能与其可改善ET-1、NT-proBNP及心衰标志物有关。Objective To study Effect of Taohong Siwu Decoction(桃红四物汤)combined with Western medicine in the treatment of heart failure complicated with angina pectoris and its influence on endothelin-1(ET-1),N-terminal B-type natriuretic peptide(NT-proBNP)and markers of heart failure.Methods Seventy-seven patients with heart failure complicated with angina pectoris who received treatment in the hospital from January 2020 to January 2022 were selected and divided into experimental group(39 cases)and control group(38 cases)by random number table method.The control group was treated with Rosuvastatin Calcium and the experimental group was treated with Taohong Siwu Decoction combined with Rosuvastatin Calcium.The clinical efficacy,ET-1,NT-proBNP,B-type natriuretic peptide(BNP),hypersensitive C-reactive protein(hs-CRP),interleukin 6(IL-6),attack frequency,duration and complications were compared between the two groups.Results After treatment,the total effective rate of the two groups was significantly different(P<0.05).After treatment,the serum levels of ET-1 and NT-proBNP were decreased in both groups,and the decrease in the experimental group was more obvious(P<0.05).After treatment,the serum levels of BNP,IL-6 and hs-CRP in two groups were decreased,and those in the experimental group were more significantly decreased(P<0.05).After treatment,the frequency and duration of attack were decreased in both groups,and the decrease in the experimental group was more obvious(P<0.05).The main complications were nausea,vomiting,dizziness and diarrhea had no significant differences between the two groups(P>0.05).Conclusion Taohong Siwu Decoction combined with Rosuvastatin Calcium has a better effect in heart failure complicated with angina pectoris,which may be related to the improvement of ET-1,NT-proBNP and markers of heart failure.

关 键 词：桃红四物汤 瑞舒伐他汀钙 心力衰竭 心绞痛 内皮素-1 N末端B型利钠肽原 心衰标志物 

分 类 号：R256.21[医药卫生—中医内科学]