基于药物代谢酶的附子配伍减毒研究进展  

Compatibility Attenuates Toxicity of Fuzi(附子)from Metabolic Enzymes:A Review

作　　者：王婧[1] 李星雨 陈思凯 卫培峰[1,2] WANG Jing;LI Xingyu;CHEN Sikai;WEI Peifeng(Shaanxi University of Chinese Medicine,Xianyang 712046;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712021)

机构地区：[1]陕西中医药大学,咸阳712046 [2]陕西中医药大学第二附属医院,咸阳712021

出　　处：《中药药理与临床》2024年第5期97-102,共6页Pharmacology and Clinics of Chinese Materia Medica

基　　金：中药大品种培育关键技术示范研究及产业化平台建设“科学家+工程师”队伍;陕西省“特支计划”人才项目;中医药“双链融合”中青年科研创新团队建设项目(编号:2022-SLRH-YQ-008);陕西中医药大学第二附属医院学科创新团队建设项目(编号:2020XKTD-A04)。

摘　　要：附子为毛茛科多年生草本植物乌头Aconitum carmichaeli Debx.的子根加工品,具有回阳救逆、散寒止痛、温阳化气的功效,在我国有着悠久的历史和独特的应用体系。由于附子存在“效毒二重性”,当过量服用和配伍不当时,其中所含的二萜类生物碱会对机体的心脏和神经系统造成严重的损坏,但其潜在机制是否与肝脏药物代谢酶的代谢相互作用有关仍不明确。本文从肝脏药物代谢酶角度阐述附子活性成分的代谢特性及其配伍对药物代谢酶的亲和作用和机制,扩大附子的用药范围,降低毒副作用,促进附子合理开发和临床安全应用,以期为附子配伍减毒增效研究提供创新思路及其合理有效应用提供参考。Fuzi(附子)is a the processed products of the branch roots of Aconitum carmichaeli Debx.,a perennial herb of Ranunculaceae.With the effects of Huiyangjiuni(回阳救逆),Sanhanzhitong(散寒止痛),and Wenyanghuaqi(温阳化气),Fuzi has a long history of medical use and a unique application system in China.The diterpenoid alkaloids contained in Fuzi can cause serious damage to the heart and nervous system in the cases of overdosing and improper compatibility.It remains unclear whether such damage is associated with the actions of drug-metabolizing enzymes in the liver.Regarding the drug-metabolizing enzymes in the liver,this article elaborates on the metabolic properties of the active components in Fuzi and the effects of compatibility on drug-metabolizing enzymes to expand the application scope,reduce the toxic and side effects,and promote the rational development and safe application of Fuzi in clinical practice,aiming to provide innovative ideas for the research on the toxicity reduction and efficacy increase by the compatibility and the rational application of Fuzi.

关 键 词：附子 药物代谢酶 CYP450 配伍 减毒 

分 类 号：R285[医药卫生—中药学]