Biomimetic Gland Models with Engineered Stratagems  

作　　者：Xiang Lin Lingyu Sun Minhui Lu Yuanjin Zhao 

机构地区：[1]Department of Rheumatology and Immunology,Nanjng Drum Tower Hospital,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China [2]Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,Zhejiang 325001,China [3]Southeast University Shenzhen Research Institute,Shenzhen 518071,China

出　　处：《Research》2024年第2期583-612,共30页研究（英文）

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(T2225003,52073060,and 61927805);the Nanjing Medical Science and Technique Development Foundation(ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);the Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).

摘　　要：As extensively distributed tissues throughout the human body,glands play a critical role in various physiological processes.Therefore,the construction of biomimetic gland models in vitro has aroused great interest in multiple disciplines.In the biological field,the researchers focus on optimizing the cell sources and culture techniques to reconstruct the specific structures and functions of glands,such as the emergence of organoid technology.From the perspective of biomedical engineering,the generation of biomimetic gland models depends on the combination of engineered scaffolds and microfluidics,to mimic the in vivo environment of glandular tissues.These engineered stratagems endowed gland models with more biomimetic features,as well as a wide range of application prospects.In this review,we first describe the biomimetic strategies for constructing different in vitro gland models,focusing on the role of microfluidics in promoting the structure and function development of biomimetic glands.After summarizing several common in vitro models of endocrine and exocrine glands,the applications of gland models in disease modelling,drug screening,regenerative medicine,and personalized medicine are enumerated.Finally,we conclude the current challenges and our perspective of these biomimetic gland models.

关 键 词：endowed CONSTRUCTING STRATA 

分 类 号：R318[医药卫生—生物医学工程]