基于Python语言探析《杂病广要》中骨伤科疾病痛症的用药规律  

Medication rule of Essentials of Expanded Miscellaneous Diseases of pain in orthopedics and traumatology diseases based on Python language

作　　者：郑洋 杨少锋[2] ZHENG Yang;YANG Shaofeng(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《湖南中医杂志》2024年第6期27-31,共5页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省自然科学基金项目(2023JJ60345,2023JJ60342);湖南省科技厅临床医疗技术创新引导项目(2020sk51405);湖南中医药大学研究生创新课题(2022CX152)。

摘　　要：目的:采用Python语言探析《杂病广要》中骨伤科疾病痛症的用药规律。方法:检索《杂病广要》中骨伤科疾病痛症的中药方剂,构建数据库,并运用Python语言分析用药频次、性味归经、功效、关联规则等。结果:共纳入方剂120首,涉及中药151味。药物使用频次共1026次,高频药物依次为炙甘草、当归、茯苓、肉桂、白芍、川芎、附子、白术。药性以温、平为主,未使用凉性药物;药味以辛、甘味为主;归经以脾、肝经为主。中药功效排名前3位的依次是补虚、解表、活血化瘀。对频次≥10次的高频药物进行层次聚类分析,得出3组药物组合,84条关联规则。结论:《杂病广要》中骨伤科疾病的核心药物为当归、白芍和川芎,并辅以补虚、温里药物以补益肝肾;同时针对外感邪气,运用解表药物以祛邪。Objective:To investigate the medication rule of Essentials of Expanded Miscellaneous Diseases of pain in orthopedics and traumatology diseases based on Python language.Methods:Essentials of Expanded Miscellaneous Diseases was searched to obtain the traditional Chinese medicine(TCM)prescriptions for the pain in orthopedics and traumatology diseases.A database was established,and Python language was used to analyze the TCM drugs from the aspects of frequency of use,nature/taste/meridian entry,function,and association rule.Results:A total of 120 prescriptions were included,involving 151 TCM drugs.There were 1026 times of drug use in total,and Radix Glycyrrhizae Preparata had the highest frequency of use,followed by Angelica sinensis,Poria cocos,cinnamon,Radix Paeoniae Alba,Rhizoma Chuanxiong,Radix Aconiti Lateralis Preparata,and Atractylodes macrocephala Koidz.Most drugs had a warm or neutral nature(without the drugs with a cold nature)and a pungent or sweet taste,and they mainly entered the spleen and liver meridians.The top three TCM functions were tonifying deficiency,relieving exterior syndrome,activating blood,and resolving stasis.A hierarchical cluster analysis was performed for the high-frequency drugs with a frequency of use of≥10 times and obtained 3 drug combinations and 84 association rules.Conclusion:Angelica sinensis,Radix Paeoniae Alba,and Rhizoma Chuanxiong are the core drugs for the orthopedics and traumatology diseases in Essentials of Expanded Miscellaneous Diseases,with the combination of deficiency-tonifying and interior-warming drugs for tonifying the liver and the kidney.Meanwhile,exterior syndrome-relieving drugs are used for exogenous pathogenic Qi to eliminate pathogens.

关 键 词：痛症 骨伤科疾病 《杂病广要》 PYTHON语言 用药规律 

分 类 号：R274[医药卫生—中医骨伤科学]