取卵日精液质量对体外受精结局的影响  

Effect of semen quality on outcome of in vitro fertilization on the day of oocyte retrieval

作　　者：胡旭[1] 吴佩蔚[1] 张琍钧 姚冠颖 HU Xu;WU Pei-wei;ZHANG Li-jun;YAO Guan-ying(Department of Reproductive Medicine,Nanyang Central Hospital,Henan 473009,China)

机构地区：[1]南阳市中心医院生殖医学科,河南南阳473009

出　　处：《医药论坛杂志》2024年第11期1201-1203,共3页Journal of Medical Forum

摘　　要：目的探讨取卵日男性精液参数与常规体外受精-胚胎移植结局的相关性。方法回顾分析2020年1月至2022年12月于南阳市中心医院生殖医学科行常规体外受精-胚胎移植的210个取卵周期,根据男方精液参数指标分为正常组和异常组,比较各组胚胎发育相关指标和临床妊娠结局,并采用logistic回归分析影响临床妊娠的相关因素。结果精子浓度正常组与异常组各个指标之间的差异无统计学意义(P>0.05)。精子活力正常组的受精率、正常受精率、优质胚胎率显著高于精子活力异常组(P=0.003、P=0.011、P=0.027)。精子总数正常组的受精率显著高于异常组(P=0.013)。精子活力正常组的临床妊娠率显著高于异常组(P=0.026),精子浓度、总数均不影响临床妊娠率、流产率和活产率(P>0.05)。二元逻辑回归分析显示精子活力是影响临床妊娠的重要因素。结论取卵日精子活力影响受精率、正常受精率及优质胚胎率,可预测临床妊娠结局。Objective To investigate the correlation between male semen parameters on oocyte retrieval day and the outcome of conventional in vitro fertilization-embryo transfer.Methods A retrospective analysis of 210 occyte retrieval cycles of conventional in vitro fertilization at Department of the Reproductive Medicine of Nanyang Central Hospital from January 2020 to December 2022.According to the parameters of male semen,they were divided into normal group and abnormal group,and the related indicators of embryo development and clinical pregnancy outcome were compared among the groups.Logistic regression was used to analyze the related factors affecting clinical pregnancy.Results There was no significant difference in sperm concentration between normal and abnormal groups(P>0.05).The fertilization rate,normal fertilization rate and high-quality embryo rate of normal sperm motility group were significantly higher than those of abnormal sperm motility group(P=0.003,P=0.011,P=0.027).The fertilization rate in the normal sperm count group was significantly higher than that of the abnormal sperm count group(P=0.013).The clinical pregnancy rate in the normal sperm motility group was significantly higher than that of the abnormal group(P=0.026),and the sperm concentration and total number did not affect the clinical pregnancy rate,abortion rate and live birth rate(P>0.05).Binary logistic regression analysis showed that sperm motility was an important factor affecting clinical pregnancy.Conclusion Sperm motility on the day of oocyte retrieval affects the fertilization rate,normal fertilization rate and high-quality embryo rate.Sperm motility can predict the clinical pregnancy outcome.

关 键 词：精液质量 受精率 临床妊娠率 

分 类 号：R714[医药卫生—妇产科学]