骨质疏松症患者PINP、25-(OH)VitD_(3)、BMP-2与中医辨证分型的相关性研究  

Study on the correlation between PINP,25-(OH)VitD_(3),BMP-2 and TCM syndrome differentiation in patients with osteoporosis

作　　者：刘莎莎[1] 郭洪科[1] LIANG Huiling;HAN Chao;ZHANG Qiuling(Department of Laboratory,Guangzhou Medical University Affiliated Traditional Chinese Medicine Hospital,Guangzhou Guangdong 510000,China)

机构地区：[1]绵阳市中心医院康复医学科,四川绵阳621000

出　　处：《四川中医》2024年第6期87-91,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:分析骨质疏松症患者血清总I型胶原氨基末端前肽(PINP)、25-羟维生素D3[25-(OH)VitD_(3)]及骨形态发生蛋白2(BMP-2)与其中医辨证分型的相关性。方法:收集我院2020年8月~2023年8月医院收治的157例骨质疏松症患者的一般资料及中医四诊资料进行回顾性分析,并统计骨质疏松症患者中医辨证分型结果,对不同症型患者基本资料、PINP、25-(OH)VitD_(3)、BMP-2水平进行比较。结果:157例骨质疏松症患者中医辨证分型属肾阳虚证34例,脾肾阳虚证43例,肝肾阴虚证49例,血瘀气滞证31例。不同中医辨证分型的骨质疏松患者血清PINP、25-(OH)VitD_(3)及BMP-2水平整体相比,差异有统计学意义(P<0.05);其中,血瘀气滞组PINP水平显著高于肾阳虚组、脾肾阳虚组及肝肾阴虚组患者(P<0.05),而其余3组两两间相比,差异无统计学意义(P>0.05);脾肾阳虚证患者25-(OH)VitD_(3)水平明显低于肾阳虚组、肝肾阴虚组及血瘀气滞组(P<0.05),且肾阳虚组低于肝肾阴虚组及血瘀气滞组(P<0.05),而其余两组相比差异无统计学意义(P>0.05);血瘀气滞组BMP-2水平显著低于肾阳虚组、脾肾阳虚组及肝肾阴虚组患者(P<0.05),而其余3组两两间相比,差异无统计学意义(P>0.05);二分类logistics回归分析结果显示,血瘀气滞与PINP呈正相关(P<0.05),与BMP-2呈负相关(P<0.05);脾肾阳虚与25-(OH)VitD_(3)呈负相关(P<0.05)。结论:骨质疏松症患者的血清PINP、25-(OH)VitD_(3)、BMP-2水平与其中医辨证分型具有一定相关性,可作为评估患者中医辨证分型的参考指标。Objective To analyze the correlation between serum total type I collagen amino terminal propeptide(PINP),25-hydroxyvitamin D3[25-(OH)VitD_(3)],bone morphogenetic protein 2(BMP-2)and TCM syndrome differentiation in patients with osteoporosis.Methods The general data and TCM four diagnostic data of 157patients with osteoporosis admitted to the hospital from August 2020to August 2023were retrospectively analyzed,and the results of TCM syndrome differentiation of osteoporosis patients were counted.The basic data,PINP,25-(OH)VitD_(3)and BMP-2levels of patients with different syndromes were compared.Results There were 34cases of kidney yang deficiency syndrome,43cases of spleen and kidney yang deficiency syndrome 49cases of liver and kidney yin deficiency syndrome,and 31cases of blood stasis and qi stagnation syndrome in 157patients with osteoporosis.The levels of serum PINP,25-(OH)VitD_(3) and BMP-2in osteoporosis patients with different TCM syndrome types were statistically significant(P<0.05).Among them,the level of PINP in the blood stasis and qi stagnation group was significantly higher than that in the kidney yang deficiency group,the spleen and kidney yang deficiency group and the liver and kidney yin deficiency group(P<0.05),while there was no significant difference between the other three groups(P>0.05).The level of 25-(OH)VitD_(3)in patients with spleen and kidney yang deficiency syndrome was significantly lower than that in kidney yang deficiency group,liver and kidney yin deficiency group and blood stasis and qi stagnation group(P<0.05),and the kidney yang deficiency group was lower than that in liver and kidney yin deficiency group and blood stasis and qi stagnation group(P<0.05),while there was no significant difference between the other two groups(P>0.05).The level of BMP-2in blood stasis and qi stagnation group was significantly lower than that in kidney yang deficiency group,spleen and kidney yang deficiency group and liver and kidney yin deficiency group(P<0.05).The results of binary logistic regressi

关 键 词：骨质疏松症 总I型胶原氨基末端前肽 25-羟维生素D3 骨形态发生蛋白2 中医辨证分型 

分 类 号：R681[医药卫生—骨科学] R589.5[医药卫生—外科学]