益气活血化痰通络汤治疗冠心病PCI术后再发心绞痛(心血瘀阻证)的临床疗效  

Clinical effect of Yiqi Huoxue Huatan Tongluo Decoction inthe treatment of angina pectoris(heart-blood stasis syndrome)after PCI for coronary heart disease

作　　者：张玉焕 王欣 胡迪 曹越 刘芳 ZHANG Yuhuan;WANG Xin;HU Di(Tangshan Traditional Chinese Medicine Hospital Traditional Chinese Medicine Department,Tangshan Hebei 063000,China)

机构地区：[1]唐山市中医医院中医科,河北唐山063000

出　　处：《四川中医》2024年第6期95-98,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(编号:2023404)。

摘　　要：目的:探究益气活血化痰通络汤治疗冠心病经皮冠状动脉介入治疗(PCI)术后再发心绞痛(AP)(心血瘀阻证)的临床疗效。方法:选取2022年6月~2023年6月本院收治的110例冠心病PCI术后再发AP患者,随机分为两组,各55例。对照组使用常规西药治疗方法,实验组在此基础上服用益气活血化痰通络汤,观察两组治疗后的临床疗效,治疗前后的中医证候积分,AP发作次数和持续时间,西雅图心绞痛量表(SAQ)评分,血脂指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)],炎症指标[高敏-C反应蛋白(hs-CRP)、白细胞介素IL-6及单核细胞趋化蛋白~1(MCP-1)],观察治疗期间两组的不良反应。结果:实验组治疗后总有效率为94.55%,对照组为76.36%,实验组高于对照组(P<0.05),实验组治疗后中医证候积分低于对照组,SAQ评分高于对照组,AP发作次数和持续时间低于对照组(P<0.05),实验组治疗后TC、TG、LDL-C、hs-CRP、IL-6、MCP-1均低于对照组(P<0.05)。两组治疗期间无明显不良反应。结论:将益气活血化痰通络汤用于冠心病PCI术后再发AP(心血瘀阻证)患者的治疗中,具有较好的临床疗效,能有效缓解AP,降低血脂,抑制炎性反应,且安全性良好。Objective:To explore the clinical curative effect of Yiqi Huoxue Huatan Tongluo Decoction in recurrent angina pectoris(AP,heart-blood stasis syndrome)after percutaneous coronary intervention(PCI)for coronary heart disease.Methods:A total of 110patients with recurrent AP after PCI for coronary heart disease in the hospital were enrolled between June 2022and June 2023,and they were randomly divided into control group(routine western medicine)and experimental group(Yiqi Huoxue Huatan Tongluo Decoction on basis of control group),55cases in each group.The clinical curative effect after treatment,scores of TCM syndromes,frequency and duration of AP onset,scores of Seattle Angina Questionnaire(SAQ),blood lipid indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)]and inflammatory indexes[high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),monocyte chemoattractant protein-1(MCP-1)]before and after treatment,and adverse reactions during treatment in the two groups were observed.Results:After treatment,total response rate of experimental group was higher than that of control group(94.55%vs 76.36%,P<0.05).After treatment,scores of TCM syndromes in experimental group were lower than those in control group,SAQ score was higher than that in control group,frequency and duration of AP onset were lower than those in control group(P<0.05).After treatment,TC,TG,LDL-C,hs-CRP,IL-6and MCP-1in experimental group were lower than those in control group(P<0.05).There were no obvious adverse reactions during treatment in either group.Conclusion:Yiqi Huoxue Huatan Tongluo Decoction has good clinical curative effect in patients with recurrent AP(heart-blood stasis syndrome)after PCI for coronary heart disease,which can effectively relieve AP,reduce blood lipid and inhibit inflammatory response,with good safety.

关 键 词：益气活血化痰通络汤 冠心病 经皮冠状动脉介入 心绞痛 心血瘀阻证 临床疗效 

分 类 号：R541.4[医药卫生—心血管疾病]