艾司西酞普兰联合阿立哌唑治疗老年精神分裂症合并抑郁患者的效果  

Effects of Escitalopram combined with Aripiprazole in treatment of elderly patients with schizophrenia complicated with depression

作　　者：王学泰 WANG Xuetai(2^(nd) Department of Psychosomatics(Psychiatry)of Qingyang Second People’s Hospital,Qingyang 745000 Gansu,China)

机构地区：[1]庆阳市第二人民医院心身(精神)二科,甘肃庆阳745000

出　　处：《中国民康医学》2024年第14期80-82,86,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察艾司西酞普兰联合阿立哌唑治疗老年精神分裂症合并抑郁患者的效果。方法:选取2021年1月至2024年1月该院收治的92例老年精神分裂症合并抑郁患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各46例。对照组给予阿立哌唑治疗,观察组在对照组基础上联合草酸艾司西酞普兰治疗。比较两组临床疗效,治疗前后抑郁程度[卡尔加里精神分裂症抑郁量表(CDSS-C)]评分、社会功能[精神障碍患者社会功能缺损评定量表(SSFD-MD)]评分、神经因子[5-羟色胺(5-HT)、多巴胺(DA)、神经营养因子-3(NT-3)]水平,以及不良反应发生率。结果:观察组治疗总有效率为91.30%(42/46),高于对照组的71.74%(33/46),差异有统计学意义(P<0.05);治疗后,两组抑郁体验、自我评价评分及CDSS-C总分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组自我照护、交流沟通、家庭生活、与人相处、社会参与等SSFD-MD评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组5-HT、DA、NT-3水平均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾司西酞普兰联合阿立哌唑治疗老年精神分裂症合并抑郁患者可提高治疗总有效率和神经因子水平,降低抑郁程度和社会功能评分,其效果优于单纯阿立哌唑治疗。Objective:To observe effects of Escitalopram combined with Aripiprazole in treatment of elderly patients with schizophrenia and depression.Methods:A prospective study was conducted on 92 elderly patients with schizophrenia and depression admitted to this hospital from January 2021 to January 2024.According to the random number table method,they were divided into control group and observation group,46 cases in each group.The control group was treated with Aripiprazole,while and the observation group was treated with Escitalopram oxalate on the basis of that of the control group.The clinical efficacy,the depression degree[Calgary depression scale for schizophrenia(CDSS-C)]score,the social function[scale of social function deficit for mantal disorders(SSFD-MD)]score,the nerve factor[5-hydroxytryptamine(5-HT),dopamine(DA),neurotrophic factor-3(NT-3)]levels before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 91.30%(42/46),which was higher than 71.74%(33/46)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the depression experience,self-evaluation scores and the total score of CDSS-C in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The SSFD-MD scores of self-care,communication,family life,getting along with people and social participation in the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).The levels of 5-HT,DA and NT-3 in the two groups were higher than those before the treatment,those in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adv

关 键 词：老年 精神分裂症 抑郁 草酸艾司西酞普兰 阿立哌唑 社会功能 神经因子 不良反应 

分 类 号：R563.9[医药卫生—呼吸系统]