桂枝茯苓丸加减联合抗生素治疗慢性盆腔炎患者的效果  

Effects of modified Guizhi Fuling capsule combined with antibiotics in treatment of patients with chronic pelvic inflammatory disease

作　　者：包艳阳 BAO Yanyang(Department of Obstetrics and Gynecology of Yuantian Community Health Service Center of Dongfeng Road,Zhengzhou 450000 Henan,China)

机构地区：[1]郑州市东风路园田社区卫生服务中心妇产科,河南郑州450000

出　　处：《中国民康医学》2024年第14期111-114,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察桂枝茯苓丸加减联合抗生素治疗慢性盆腔炎患者的效果。方法:选取2020年12月至2022年2月该院收治的76例慢性盆腔炎患者进行前瞻性研究,按随机数字表法将其分为对照组与观察组各38例。对照组给予常规抗生素治疗,观察组在对照组基础上联合桂枝茯苓丸加减治疗。比较两组临床疗效,治疗前后中医证候积分、疼痛程度[视觉模拟评分法(VAS)]评分、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)]水平,以及不良反应发生率和复发率。结果:观察组治疗总有效率为97.37%(37/38),高于对照组的78.95%(30/38),差异有统计学意义(P<0.05);治疗后,两组下腹坠痛或隐痛、腰骶胀痛、附件区压痛、带下异常等中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6、TNF-α、CRP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);观察组复发率为7.89%(3/38),低于对照组的26.32%(10/38),差异有统计学意义(P<0.05)。结论:桂枝茯苓丸加减联合抗生素治疗慢性盆腔炎患者可提高治疗总有效率,降低中医证候积分、疼痛程度评分、炎性因子水平和复发率,其效果优于常规抗生素治疗。Objective:To observe effects of modified Guizhi Fuling capsule combined with antibiotics in treatment of patients with chronic pelvic inflammatory disease.Methods:A prospective study was conducted on 76 patients with chronic pelvic inflammatory disease admitted to the hospital from December 2020 to February 2022.According to the random number table method,they were divided into control group and observation group,38 cases in each group.The control group was treated with conventional antibiotics,while the observation group was treated with Guizhi Fuling capsule on the basis of that of the control group.The clinical efficacy,the TCM syndrome score,the pain degree[visual analogue scale(VAS)]score,the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)]levels before and after the treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results:The total effective rate of the observation group was 97.37%(37/38),which was higher than 78.95%(30/38)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the scores of TCM syndromes such as lower abdominal pain or dull pain,lumbosacral pain,tenderness in the attachment area,and abnormal vaginal discharge in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The VAS scores of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6,TNF-αand CRP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.

关 键 词：桂枝茯苓丸 抗生素 慢性盆腔炎 中医证候积分 疼痛 炎性因子 

分 类 号：R271.9[医药卫生—中西医结合]