中性粒细胞胞外诱捕网在热射病中的作用机制研究进展  

Research Progress of Mechanism of Neutrophil Extracellular Traps in Heat Stroke

作　　者：常林遇 范文文 张静 倪军 CHANG Linyu;FAN Wenwen;ZHANG Jing;NI Jun(Graduate School,Xinxiang Medical University,Xinxiang 453000,China;Department of Hematology and Endocrinology,Chinese PLA 83rd Army Hospital,Xinxiang 453000,China)

机构地区：[1]新乡医学院研究生学院,河南新乡453000 [2]陆军第八十三集团军医院血液内分泌科,河南新乡453000

出　　处：《医学综述》2024年第16期1927-1930,1936,共5页Medical Recapitulate

基　　金：军队后勤科研计划项目(CLJ20J026)。

摘　　要：热射病是一种因机体核心温度过高引发的全身炎症反应性疾病,其特征包括中枢神经系统功能障碍和多器官功能衰竭。中性粒细胞胞外诱捕网(NETs)是由中性粒细胞受各种病原体和炎症因子刺激后产生的一种网状结构,在热射病的发生发展中发挥重要作用,但其具体作用机制目前尚未完全阐明。因此,未来深入研究NETs在热射病中的作用机制,可以为热射病的治疗提供新思路。Heat stroke is a systemic inflammatory response disease caused by excessive core temperature of the body,characterized by central nervous system dysfunction and multiple organ failure.Neutrophil extracellular traps(NETs)are a type of network produced by neutrophils stimulated by various pathogens and inflammatory factors,which plays an important role in the development of heat stroke,but the specific mechanism of action has not been fully elucidated.Therefore,future in-depth studies of the mechanism of NETs in heat stroke can provide new ideas for the treatment of heat stroke.

关 键 词：热射病 中性粒细胞胞外诱捕网 治疗靶点 

分 类 号：R129[医药卫生—环境卫生学]